Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tim D. Spector"'
Publikováno v:
British Journal of Nutrition
CVD is the leading cause of death worldwide and, after dementia, is the second biggest cause of death for women. In England, it accounts for one in four of all deaths. Lifestyle modifications represent the primary route both to reduce CVD risk factor
Autor:
Massimo Mangino, Christopher J Hammond, Tim D. Spector, Claire J. Steves, Cristina Menni, Caroline I. Le Roy, Richard Davies, Simon Couvreur, Frances M K Williams, Mario Falchi, Ruth C. E. Bowyer, Carole H. Sudre, Olatz Mompeo, Maxim B. Freidin, Alessia Visconti
Publikováno v:
Twin Research and Human Genetics
Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n = 3261) completing the C-19 COVID-19 symptom tracker app allowed classical twin studies of COVID-19 symptoms, including predicted COVID-19, a sym
Autor:
Darioush Yarand, Ruth C. E. Bowyer, Paraskevi Christofidou, Cristina Menni, Jordana T. Bell, Genevieve Lachance, Serena Verdi, Kerrin S. Small, Deborah J. Hart, Massimo Mangino, Claire J. Steves, Golboo Abbasian, Tim D. Spector, Frances M K Williams, Mario Falchi, Christopher J Hammond
Publikováno v:
Twin Research and Human Genetics. 22:523-529
TwinsUK is the largest cohort of community-dwelling adult twins in the UK. The registry comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets); it is predominantly female (82%) and middle-aged (mean age 59). In addition,
Autor:
Andrew T. Chan, Tim D. Spector, Sarah Berry, Paul W. Franks, Ana M. Valdes, Nicola Segata, Richard Davies, David A. Drew
Publikováno v:
Proceedings of the Nutrition Society. 79
Postprandial lipemia is an independent risk factor for CVD, due to effects on lipoprotein remodelling, oxidative stress, inflammation, haemostasis and endothelial dysfunction. However, it is unknown whether the total, peak or duration of the lipemic
Autor:
Andrew T. Chan, Nicola Segata, Tim D. Spector, Richard Davies, Sarah Berry, Paul W. Franks, David A. Drew, Ana M. Valdes
Publikováno v:
Proceedings of the Nutrition Society. 79
Glycemic, insulinemic and lipemic postprandial responses are multi-factorial and contribute to diabetes, obesity and CVD. The aim of the PREDICT I study is to assess the genetic, metabolic, metagenomic, and meal-context contribution to postprandial r
Publikováno v:
Twin Research and Human Genetics. 19:600-609
Our study examines the contribution of genetic and environmental factors (both shared and unique) to frailty, measured using the Rockwood Frailty Index (FI) in a sample of twins from the St Thomas’ UK Adult Twin Registry. The FI was based on 39 ite
Autor:
Deborah J. Hart, Christopher J Hammond, Harold Snieder, Alireza Moayyeri, Tim D. Spector, Claire J. Steves
Publikováno v:
Twin research and human genetics, 19(1), 27-34. Cambridge University Press
Moayyeri, A, Hart, D J, Snieder, H, Hammond, C J, Spector, T D & Steves, C J 2016, ' Aging Trajectories in Different Body Systems Share Common Environmental Etiology : The Healthy Aging Twin Study (HATS) ', TWIN RESEARCH AND HUMAN GENETICS, vol. 19, no. 1, pp. 27-34 . https://doi.org/10.1017/thg.2015.100
Moayyeri, A, Hart, D J, Snieder, H, Hammond, C J, Spector, T D & Steves, C J 2016, ' Aging Trajectories in Different Body Systems Share Common Environmental Etiology : The Healthy Aging Twin Study (HATS) ', TWIN RESEARCH AND HUMAN GENETICS, vol. 19, no. 1, pp. 27-34 . https://doi.org/10.1017/thg.2015.100
Little is known about the extent to which aging trajectories of different body systems share common sources of variance. We here present a large twin study investigating the trajectories of change in five systems: cardiovascular, respiratory, skeleta
Publikováno v:
Psychological Medicine. 41:2435-2445
BackgroundThe DSM-V Working Group is currently re-evaluating distress as a primary diagnostic criterion for female sexual dysfunction (FSD). Here, for the first time, we explored the epidemiology of sexual distress and its putative aetiological relat
Autor:
Tim D. Spector, Andrea V. Burri
Publikováno v:
Twin Research and Human Genetics. 14:240-248
Postcoital psychological symptoms (PPS) is a virtually unexplored phenomenon in the female population even though women frequently complain about irritability and motiveless crying after intercourse and/or orgasm. The aim of this study was to explore
Autor:
Janine H. Stubbe, Belinda K. Cornes, Jacqueline M. Vink, Lynn Cherkas, Marleen H.M. de Moor, Eco J. C. de Geus, Nancy L. Pedersen, Urho M. Kujala, Nicholas G. Martin, Jaakko Kaprio, Dorret I. Boomsma, Tim D. Spector, Jennifer R. Harris, Kirsten Ohm Kyvik, Richard J. Rose, Sarah E. Medland, Axel Skytthea
Publikováno v:
Vink, J M, Boomsma, D I, Medland, S E, de Moor, M H M, Stubbe, J H, Cornes, B K, Martin, N G, Skytthea, A, Kyvik, K O, Rose, R J, Kujala, U, Kaprio, J, Harris, J R, Pedersen, N L, Cherkas, L F, Spector, T D & de Geus, E J C 2011, ' Variance Components Models for Physical Activity With Age as Modifier: A Comparative Twin Study in Seven Countries ', Twin Research and Human Genetics, vol. 14, no. 1, pp. 25-34 . https://doi.org/10.1375/twin.14.1.25
Twin Research and Human Genetics, 14(1), 25-34. Australian Academic Press
Twin Research and Human Genetics, 1, 14, 25-34
Vink, J M, Boomsma, D I, Medland, S E, de Moor, M H M, Stubbe, J H, Cornes, B K, Martin, N G, Skytthe, A, Kyvik, K O, Rose, R J, Kujala, U M, Kaprio, J, Harris, J R, Pedersen, N L, Cherkas, L, Spector, T D & de Geus, E J C 2011, ' Variance components models for physical activity with age as modifier: a comparative twin study in seven countries ', Twin Research and Human Genetics, vol. 14, no. 1, pp. 25-34 . https://doi.org/10.1375/twin.14.1.25
Twin Research and Human Genetics, 14(1), 25-34. Australian Academic Press
Twin Research and Human Genetics, 1, 14, 25-34
Vink, J M, Boomsma, D I, Medland, S E, de Moor, M H M, Stubbe, J H, Cornes, B K, Martin, N G, Skytthe, A, Kyvik, K O, Rose, R J, Kujala, U M, Kaprio, J, Harris, J R, Pedersen, N L, Cherkas, L, Spector, T D & de Geus, E J C 2011, ' Variance components models for physical activity with age as modifier: a comparative twin study in seven countries ', Twin Research and Human Genetics, vol. 14, no. 1, pp. 25-34 . https://doi.org/10.1375/twin.14.1.25
Physical activity is influenced by genetic factors whose expression may change with age. We employed an extension to the classical twin model that allows a modifier variable, age, to interact with the effects of the latent genetic and environmental f