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pro vyhledávání: '"Marlana Orloff"'
Autor:
Ying Liu, Kedan Lin, Yan Wang, Nehal Lakhani, Fang Liu, Siqing Fu, Shuling Yan, Marlana Orloff, Hui Zhou, Amita Patnaik
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background IBI188 is a humanized IgG4 monoclonal antibody targeting CD47, an antiphagocytic (‘don’t eat me’) signal present on cancer cells. Blockage of this myeloid checkpoint, IBI188 enhances tumor cell phagocytosis and cross priming of T-cel