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Autor:
Kazuhiro Usui, Osamu Hataji, Daichi Fujimoto, Toshiyuki Kozuki, Ryoji Kato, Noriyuki Ebi, Sho Saeki, Tomohiro Ozaki, Junichi Shimizu, Yasutaka Chiba, Shunsuke Teraoka, Keiichi Ota, Kazuhiko Nakagawa, Motoyasu Okuno, Kentaro Tanaka, Atsushi Nakamura, Kazumi Nishino, Eriko Miyawaki, Nobuyuki Yamamoto, Yuki Akazawa, Ryo Toyozawa, Hidetoshi Hayashi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundStudies have suggested that chemotherapy after immune checkpoint inhibitors may confer an improved response for non–small cell lung cancer (NSCLC). However, potential selection bias in such studies has not been addressed. We therefore app
Autor:
Peng Zhang, Kejin Wu, Hongliang Chen, Bin Li, Mingdi Zhang, Fang Bai, Yipeng Fu, Dan Li, Qianru Huang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundRegulatory T (Treg) cells play a negative role in anti-tumor immunity against triple-negative breast cancer, so it is of great significance to find the potential therapeutic target of Treg cells.MethodsFirst, Annexin A1 (ANXA1) expression a
Autor:
Anita Giobbie-Hurder, Daniel Y. Wang, Melissa A. Lumish, Michael Dougan, Douglas B. Johnson, Alexandra Coromilas, Meghan J. Mooradian, Tianqi Chen, Ryan J. Sullivan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundImmune-related colitis is a common, often serious complication of immune checkpoint inhibition (ICI). Although endoscopy is not strictly recommended for any grade of diarrhea/colitis, emerging evidence suggests that endoscopic evaluation ma
Autor:
Haiying Sun, Marcus O. Butler, Sunil Sharma, Jason E. Faris, Hongqian Wu, Jennifer Marie Mataraza, Andrea Varga, Todd M. Bauer, Jan H.M. Schellens, Antonio P. Silva, Justin F. Gainor, Chia-Chi Lin, Scott Cameron, Matthew H. Taylor, Aung Naing, Hans Gelderblom, Maria Ochoa de Olza, Patrick M. Forde
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for ImmunoTherapy of Cancer, 8(1). BMJ PUBLISHING GROUP
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, 8(1). BMJ PUBLISHING GROUP
Journal for Immunotherapy of Cancer
BackgroundSpartalizumab is a humanized IgG4κ monoclonal antibody that binds programmed death-1 (PD-1) and blocks its interaction with PD-L1 and PD-L2. This phase 1/2 study was designed to assess the safety, pharmacokinetics, and preliminary efficacy
Autor:
Wei Zhang, Zhenli Li, Wang Yingchao, Geng Chen, Cai Zhixiong, Youshi Zheng, Su Xiaoping, Kun Ke, Yongyi Zeng, Jingfeng Liu, Xiaolong Liu, Liman Qiu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundCollecting duct carcinoma (CDC) of the kidney is a rare and highly aggressive malignant tumor with the worst prognosis among all renal cancers. Nevertheless, the first-line treatments, including chemotherapy and target therapy, usually show
Autor:
Alejandro Meraz-Munoz, Claire Ragobar, Ron Wald, Pamela Ng, Carmen Avila-Casado, Joseph Kim, Eitan Amir, Abhijat Kitchlu, Christopher T. Chan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundImmune checkpoint inhibitors (ICPi) are a novel and promising anti-cancer therapy. There are limited data on the incidence, risk factors and outcomes of acute kidney injury (AKI) in patients receiving ICPi.MethodsWe conducted a cohort study
Autor:
Saskia J. A. M. Santegoets, Els M. E. Verdegaal, Ellen Kapiteijn, Caroline E. van der Minne, Noel F C C de Miranda, Monique K van der Kooij, Marij J. P. Welters, Linda de Bruin, Anton G. T. Terwisscha van Scheltinga, Pauline Meij, Gerrit-Jan Liefers, Marten Visser, Inge Roozen, Sjoerd H. van der Burg
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for ImmunoTherapy of Cancer, 8(1). BMJ PUBLISHING GROUP
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, 8(1). BMJ PUBLISHING GROUP
Journal for Immunotherapy of Cancer
BackgroundAdoptive cell therapy (ACT) with tumor-reactive T cells has shown consistent clinical efficacy. We evaluated the response to ACT in combination with interferon alpha (IFNa) preconditioning in patients with stage IV metastatic melanoma, most
Autor:
Adrien Costantini, Paul Takam Kamga, Thierry Chinet, Jean-François Emile, Etienne Giroux Leprieur, Simon Garinet, Sylvie Labrune, Alexandre Corjon, Zofia Hélias-Rodzewicz, Coraline Dumenil, Catherine Julie, Violaine Giraud, Jennifer Dumoulin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer, BMJ Publishing Group 2020, 8 (1), ⟨10.1136/jitc-2020-000527⟩
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer, BMJ Publishing Group 2020, 8 (1), ⟨10.1136/jitc-2020-000527⟩
BackgroundDespite prolonged tumor response to immune checkpoint inhibitors (ICIs) for a subset of patients with advanced non-small cell lung cancer (NSCLC), a secondary resistance will occur for a majority of these patients. The understanding of late
Publikováno v:
ESMO Open
ESMO Open, 5 (3
ESMO Open, Vol 5, Iss 3 (2020)
ESMO Open, 5 (3
ESMO Open, Vol 5, Iss 3 (2020)
PURPOSE: Pseudocirrhosis is a radiological term used to describe rapid changes in the contour of liver invaded by metastases and treated with chemotherapy. Our primary objectives were to analyse the clinical and biological characteristics of those pa
Autor:
Fatima Karzai, Beatriz Walter-Rodriguez, Houssein Abdul Sater, Marijo Bilusic, Jennifer L. Marte, Seth M. Steinberg, Renee N. Donahue, James L. Gulley, Christopher R. Heery, William L. Dahut, Guinevere Chun, Peter A. Pinto, Ravi A. Madan, Ismail B. Turkbey, Lisa M. Cordes, Stephanie Harmon, Peter L. Choyke, Jeffrey Schlom
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundClinical trials have shown the ability of therapeutic vaccines to generate immune responses to tumor-associated antigens (TAAs). What is relatively less known is if this translates into immune-cell (IC) infiltration into the tumor microenvi