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Autor:
Wenli Cai, Jian Huang, Qiong Wang, Kewei Xu, Xiangyu Zhan, Kai Yao, Qianghua Zhou, Kaiwen Li, Wei Yao, Xingxing Zang, Hai Huang, Shirong Peng, Yiming Lai
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
BackgroundAlthough immune checkpoint inhibitors (ICIs), especially programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) axis blockers, exhibit prominent antitumor effects against numerous malignancies, their benefit for patients w
Autor:
Peixin Chen, Chunyan Wu, Minlin Jiang, Yi Xu, Liping Zhang, Jun Zhu, Chenglong Sun, Yayi He, Jia Yu, Caicun Zhou, Shengyu Wu, Hao Wang, Qiyu Fang, Hui Sun, Wencheng Zhao, Zixuan Zheng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundImmunotherapies may prolong the survival of patients with small-cell lung cancer (SCLC) to some extent. The role of forkhead box protein P3 (FOXP3) in tumor microenvironment (TME) remains controversial. We aimed to examine FOXP3-related exp
Autor:
Stefan Traint, Sebastian Bauer, Thomas Brodowicz, Gerwin Heller, Katharina Feldmann, Julia Furtner, Gabriele Amann, Rainer Hamacher, Teresa Hatziioannou, Iris M. Noebauer-Huhmann, Leonhard Müllauer, Wolfgang Lamm, Angelika M. Starzer, Erwin Tomasich, Hans-Ulrich Schildhaus, Anna S. Berghoff, Matthias Preusser
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundSome sarcomas respond to immune checkpoint inhibition, but predictive biomarkers are unknown. We analyzed tumor DNA methylation profiles in relation to immunological parameters and response to anti-programmed cell death 1 (anti-PD-1) immune
Autor:
Marco Marchisio, Emma Di Carlo, Carlo Sorrentino, Li-Fan Lu, Matteo Bellone, Paola Lanuti, Zhinan Yin, Stefania Livia Ciummo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
Background Interleukin(IL)-30/IL-27p28 production by Prostate Cancer (PC) Stem-Like Cells (SLCs) has proven, in murine models, to be critical to tumor onset and progression. In PC patients, IL-30 expression by leukocytes infiltrating PC and draining