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Publikováno v:
Annals of the Rheumatic Diseases
Objectives To confirm the effectiveness and safety of the interleukin 6-receptor antagonist tocilizumab in patients with rheumatoid arthritis (RA) in a setting close to real-life medical care in Germany. Methods A multicentre open-label phase IIIb st
Publikováno v:
Annals of the Rheumatic Diseases
Background:Population mean changes from clinical trials are difficult to apply to individuals in clinical practice. Responder analysis may be better, but needs validating for level of response and treatment duration.Methods:The numbers of patients wi
Publikováno v:
BMJ Open
Introduction Chronic heart failure in Baltic Sea Region is responsible for more hospitalisations than all forms of cancer combined and is one of the leading causes of hospitalisations in elderly patients. Frequent hospitalisations, along with other d
Autor:
Lijing L. Yan, Zhaohui Cui, Xiaoyan Shi, Yangfeng Wu, Michael J. Dibley, Yongping Pan, Aiyu Gao, Smita Shah
Publikováno v:
BMJ Open
Objective To evaluate the effect on physical activity and sedentary behaviour of a pilot school-based peer education programme in urban Beijing, China. Design 4 junior high schools were matched by school size and randomised to intervention (n=346) an
Autor:
Howard Berger, Y. Ingrid Goh, Gideon Koren, Sondra vanderVaart, Anna Taddio, Saskia N. de Wildt, Carolyn Tam, Violette M G J Gijsen
Publikováno v:
BMJ Open
BMJ Open Gastroenterology, 1:e000021. BMJ Publishing Group
BMJ Open Gastroenterology, 1:e000021. BMJ Publishing Group
Introduction Approximately 25% of all babies in North America are delivered via Caesarean section (C-section). Though a common surgical procedure, C-section recovery can be painful. Opioids, specifically codeine, are commonly used to ease pain; howev
Autor:
Guang-Zhong Yang, Louis Atallah, Ara Darzi, Benny Lo, Thanos Athanasiou, Omer Aziz, Edward Gray
Patients' functional recovery at home following surgery may be evaluated by monitoring their activities of daily living. Existing tools for assessing these activities are labor-intensive to administer and rely heavily on recall. This study describes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc6a18a7a923aca0edd1cf0b8316e54
https://europepmc.org/articles/PMC3116260/
https://europepmc.org/articles/PMC3116260/
In preparation for randomised controlled trials (RCTs) of disease-modifying antirheumatic drugs in patients with early inflammatory arthritis (EIA), formative research was conducted to enhance the design of such trials. The objectives of this researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09b59960fd407a70333fa3aa5896e99
https://europepmc.org/articles/PMC1856056/
https://europepmc.org/articles/PMC1856056/
Autor:
Tahir Masud, Alexander J E Foss, Francis Osborn, Richard M. Gregson, Rowan H. Harwood, Tracey Sach, Anwar Zaman
To evaluate the cost-effectiveness of first eye cataract surgery compared with no surgery from a health service and personal social services perspective.An economic evaluation undertaken alongside a randomised controlled trial of first eye cataract s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7144874819d6c0259b452b2e0e88c6b
https://europepmc.org/articles/PMC2095519/
https://europepmc.org/articles/PMC2095519/
Autor:
Smolen, J. S., Keystone, E. C., Emery, P., Breedveld, F. C., Betteridge, N., Burmester, G. R., Dougados, M., Ferraccioli, G., Jaeger, U., Klareskog, L., Kvien, T. K., Martin Mola, E., Pavelka, K., Carbonell, Jordi, Combe, Bernard, Cutolo, Maurizio, Dörner, Thomas, Gause, Angela, Gomez Reino, Juan, Fernandes, Carlos Gonzales, Isaacs, John D., Marenco, José Luis, Mariette, Xavier, Matucci Cerinic, Marco, Montecucco, Carlo Maurizio, Nüßlein, Hubert, Østergaard, Mikkel, Pascual, Eliseo, Van Riel, Piet, Rubbert, Andrea, Sanmarti, Raimon, Sekanecz, Zoltan, Tak, Paul Peter, Tony, Hans Peter, Valesini, Guido, VALENTINI, Gabriele
A large number of experts experienced in the treatment of rheumatoid arthritis were involved in formulating a consensus statement on the use of B cell-targeted treatment with rituximab in patients with rheumatoid arthritis. The statement was supporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd64979d2d74b5250e7190eaf5c2027f
https://europepmc.org/articles/PMC1798500/
https://europepmc.org/articles/PMC1798500/
Autor:
Justin Travers, Brent Caldwell, Sarah Aldington, Suzanne Marsh, Mark Weatherall, Philippa Shirtcliffe, Mathew Williams, Richard Beasley
Background: Asthma is a heterogeneous disease with a wide range of clinical phenotypes, not all of which may be encompassed in the subjects included in randomised controlled trials (RCTs). This makes it difficult for clinicians to know to what extent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42838d9961aef7a271cddefe06dcf10d
https://europepmc.org/articles/PMC2117157/
https://europepmc.org/articles/PMC2117157/