Zobrazeno 241 - 250
of 404
pro vyhledávání: ''
Publikováno v:
International Journal of Gynecological Cancer. 21:981-987
Objective: CXC chemokine receptor 4 (CXCR4) was considered to be an important factor in cancer cell metastasis. This study was aimed to examine the expression of CXCR4 in ovarian cancer and determine the functions and the possible mechanisms of CXCR4
Autor:
Ji-Youn Han, Geon Kook Lee, Kyong-Ah Yoon, Heung Tae Kim, Seog-Yun Park, Tak Yun, Kun Young Lim, Young-Woong Won, Jin Soo Lee
Publikováno v:
Journal of Clinical Pathology. 64:947-952
Aims Deletion of exon 19 of the epidermal growth factor receptor (EGFR) and mutation of exon 21 are the most common EGFR mutations and predict higher response to EGFR tyrosine kinase inhibitors (TKI). Accumulating data show clinical differences in bo
Autor:
Makiko Fujii, Yasuyuki Okamoto, Yutaka Kondo, Toshirou Nishida, Hiromu Suzuki, Akira Sawaki, Seiji Ito, Hiromi Kataoka, Yasuhisa Shinomura, Hideki Murakami, Yoshitaka Sekido, Ichiro Takeuchi, Minoru Toyota, Hirotaka Osada, Keiko Shinjo, Takashi Joh, Tsuyoshi Takahashi, Kenji Yamao, Byonggu An, Hidemi Ito
Publikováno v:
Gut. 61:392-401
Background and aims The majority of gastrointestinal stromal tumors (GISTs) have KIT mutations; however, epigenetic abnormalities that could conceivably potentiate the aggressiveness of GISTs are largely unidentified. Our aim was to establish epigene
Publikováno v:
Journal of Clinical Pathology. 64:1078-1082
BackgroundMatrix metalloproteinases (MMP), particularly MMP-2 and MMP-9, participate in tumour progression and metastasis in various cancers. Their significance in urothelial cancer of the bladder (UCB) is unclear. Expression analysis of MMP-2 and MM
Autor:
Pär-Ola Bendahl, Mef Nilbert, Ana Carneiro, Anders Rydholm, Måns Åkerman, Jacob Engellau, Henryk A. Domanski
Publikováno v:
Journal of Clinical Pathology. 64:689-694
Background Ezrin is a cytoskeletal protein involved in tumour growth and invasion. Ezrin expression has been suggested to play a role in metastasis in paediatricosteosarcoma and rhabdomyosarcoma. Aim To evaluate the prognostic role of ezrin in a larg
Publikováno v:
Journal of Clinical Pathology. 64:751-755
Colorectal gastrointestinal stromal tumours (GISTs) are considered to be tumours with a relatively poor prognosis. Few reports have been performed to investigate the mechanisms behind their malignant behaviour and to identify new therapeutic strategi
Autor:
Hans-Peter Tony, Thomas Seibold, Hermann Einsele, Petra Roll, Thomas Dörner, Khalid Muhammad, Stefan Kleinert
Publikováno v:
Annals of the Rheumatic Diseases. 70:1507-1510
Interleukin 6 (IL-6) receptor (IL-6R) inhibition by tocilizumab is a novel anti-inflammatory therapy for rheumatoid arthritis (RA) patients. As IL-6 is a late differentiation factor of B cells the authors asked if IL-6R inhibition impacts on the muta
Autor:
Moshe Yaniv, Oliver Distler, Alfiya Akhmetshina, Jérôme Avouac, Katrin Palumbo, Michal Tomcik, Pawel Zerr, Clara Dees, Jörg H W Distler, Georg Schett, Stefan Vollath
Publikováno v:
Annals of the Rheumatic Diseases. 70:1320-1326
Objectives Transforming growth factor β (TGFβ) has been identified as a key player in fibrotic diseases. However, the molecular mechanisms by which TGFβ activates fibroblasts are incompletely understood. Here, the role of JunD, a member of the act
Publikováno v:
Journal of Clinical Pathology. 64:578-586
To elucidate the clinicopathological significance of Y416Src and Y527Src expression in breast cancer, and to evaluate their usefulness as potential predictive markers for Src inhibitors.c-Src is a non-receptor tyrosine kinase; the active form of c-Sr
Autor:
Loukia Tsaprouni, Gaetano Caramori, Gino Villetti, Elen Jazrawi, Paolo Casolari, Ian M. Adcock, Peter J. Barnes, Kazuhiro Ito, Chiara Carnini, Alberto Papi, Kian Fan Chung, Maurizio Civelli
Publikováno v:
Thorax. 66:521-527
Chronic obstructive pulmonary disease (COPD) is characterised by oxidative stress and increased risk of lung carcinoma. Oxidative stress causes DNA damage which can be repaired by DNA-dependent protein kinase complex.To investigate DNA damage/repair