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Akademický článek
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Akademický článek
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Autor:
Ghanem Ghanem, Piccart Martine, Najar Mehdi, Lagneaux Laurence, Id Boufker Hichame, Body Jean-Jacques, Journé Fabrice
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 298 (2010)
Abstract Background The proto-oncogene Src is an important non-receptor protein tyrosine kinase involved in signaling pathways that control cell adhesion, growth, migration and differentiation. It negatively regulates osteoblast activity, and, as suc
Externí odkaz:
https://doaj.org/article/f6cc8459cebf417aa89723e83c724eb4
Autor:
Piccart Martine, Larsimont Denis, Harris Adrian L, Rouas Ghizlane, Desmedt Christine, Haibe-Kains Benjamin, Sieuwerts Anieta M, Toussaint Jérôme, Foekens John A, Durbecq Virginie, Sotiriou Christos
Publikováno v:
BMC Genomics, Vol 10, Iss 1, p 424 (2009)
Abstract Background Proliferation and tumor differentiation captured by the genomic grade index (GGI) are important prognostic indicators in breast cancer (BC) especially for the estrogen receptor positive (ER+) disease. The aims of this study were t
Externí odkaz:
https://doaj.org/article/ee7b362f0ce94339a4a31d8d8b3683e5
Autor:
Haibe-Kains Benjamin, Viale Giuseppe, Lallemand Françoise, Smeets Ann, Christiaens Marie-Rose, Paridaens Robert, Neven Patrick, Giobbie-Hurder Anita, Desmedt Christine, Gelber Richard D, Piccart Martine, Sotiriou Christos
Publikováno v:
BMC Medical Genomics, Vol 2, Iss 1, p 40 (2009)
Abstract Background We have previously shown that the Gene expression Grade Index (GGI) was able to identify two subtypes of estrogen receptor (ER)-positive tumors that were associated with statistically distinct clinical outcomes in both untreated a
Externí odkaz:
https://doaj.org/article/6522b960193d448688cf240dc8de0e1a
Autor:
Conus Nelly M, Lallemand Francoise, Haibe-Kains Benjamin, Sotiriou Christos, Loi Sherene, Piccart Martine J, Speed Terence P, McArthur Grant A
Publikováno v:
BMC Medical Genomics, Vol 2, Iss 1, p 37 (2009)
Abstract Background Within estrogen receptor-positive breast cancer (ER+ BC), the expression levels of proliferation-related genes can define two clinically distinct molecular subtypes. When treated with adjuvant tamoxifen, those ER+ BCs that are low
Externí odkaz:
https://doaj.org/article/fe45486aaf7a4661b4f9f5be1793a12b
Autor:
van't Veer Laura, Cardoso Fatima, Buyse Marc, Piette Fanny, Desmedt Christine, Haibe-Kains Benjamin, Piccart Martine, Bontempi Gianluca, Sotiriou Christos
Publikováno v:
BMC Genomics, Vol 9, Iss 1, p 394 (2008)
Abstract Background During the last years, several groups have identified prognostic gene expression signatures with apparently similar performances. However, signatures were never compared on an independent population of untreated breast cancer pati
Externí odkaz:
https://doaj.org/article/b635899c18c54e358e50047651125745
Autor:
Daidone Maria G, Reid James F, Ellis Paul, Ryder Kenneth, Gillet Cheryl, Tutt Andrew M, Lallemand Françoise, Wirapati Pratyaksha, Desmedt Christine, Haibe-Kains Benjamin, Loi Sherene, Pierotti Marco A, Berns Els MJJ, Jansen Maurice PHM, Foekens John A, Delorenzi Mauro, Bontempi Gianluca, Piccart Martine J, Sotiriou Christos
Publikováno v:
BMC Genomics, Vol 9, Iss 1, p 239 (2008)
Abstract Background Estrogen receptor positive (ER+) breast cancers (BC) are heterogeneous with regard to their clinical behavior and response to therapies. The ER is currently the best predictor of response to the anti-estrogen agent tamoxifen, yet
Externí odkaz:
https://doaj.org/article/4f2f1ec391734747b633dd5d6cdc8293