Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Scarpa A"'
Autor:
Quan Zheng, Jiajia Tang, Alexandra Aicher, Tony Bou Kheir, Berina Sabanovic, Preeta Ananthanarayanan, Chiara Reina, Minchun Chen, Jian-Min Gu, Bin He, Sonia Alcala, Diana Behrens, Rita T. Lawlo, Aldo Scarpa, Manuel Hidalgo, Bruno Sainz, Patricia Sancho, Christopher Heeschen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-21 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a profoundly aggressive and fatal cancer. One of the key factors defining its aggressiveness and resilience against chemotherapy is the existence of cancer stem cells (CSCs). The importan
Externí odkaz:
https://doaj.org/article/2d7e2a41ca1e428c8e2dfa1def3561de
Autor:
Brocco Giorgio, Bonora Antonio, Barbi Stefano, Furlan Federico, Mafficini Andrea, Sorio Claudio, Blasi Francesco, Talamini Giorgio, Bassi Claudio, Scarpa Aldo
Publikováno v:
BMC Cancer, Vol 11, Iss 1, p 448 (2011)
Abstract Background The urokinase plasminogen activator receptor is highly expressed and its gene is amplified in about 50% of pancreatic ductal adenocarcinomas; this last feature is associated with worse prognosis. It is unknown whether the level of
Externí odkaz:
https://doaj.org/article/7877a64ead924d568224ad546067ede5
Autor:
Pelosi Giuseppe, Boninsegna Letizia, Debattisti Valentina, Fumagalli Caterina, Dandrea Mario, Amato Eliana, Malpeli Giorgio, Falconi Massimo, Scarpa Aldo
Publikováno v:
BMC Cancer, Vol 11, Iss 1, p 351 (2011)
Abstract Background RASSF1A gene silencing by DNA methylation has been suggested as a major event in pancreatic endocrine tumor (PET) but RASSF1A expression has never been studied. The RASSF1 locus contains two CpG islands (A and C) and generates sev
Externí odkaz:
https://doaj.org/article/cf9441b84cb94ca2906e016dfe85c64a
Autor:
Mattuzzi Silvia, Lamba Simona, Bersani Samantha, De Manzoni Giovanni, Cataldo Ivana, Barbi Stefano, Bardelli Alberto, Scarpa Aldo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 29, Iss 1, p 32 (2010)
Abstract Background PIK3CA is one of the genes most frequently mutated in human cancers and it is a potential target for personalized therapy. The aim of this study was to assess the frequency and type of PIK3CA mutations in gastric carcinoma and com
Externí odkaz:
https://doaj.org/article/fe857c7b903c4134b6cd1deaf581f98f
Publikováno v:
Molecular Cancer, Vol 9, Iss 1, p 61 (2010)
Abstract Background Our understanding of the mechanism regulating pancreatic cancer metastatic phenotype is limited. We analyzed the role of RHOA and PRKCZ in the motility attitude of two subclones of the pancreatic adenocarcinoma cell line SUIT-2 (S
Externí odkaz:
https://doaj.org/article/46cb68b5ed444f0e8c52aaf48c312610
Publikováno v:
Molecular Cancer, Vol 2, Iss 1, p 7 (2003)
Abstract The incidence and mortality of pancreatic adenocarcinoma are nearly coincident having a five-year survival of less than 5%. Enormous advances have been made in our knowledge of the molecular alterations commonly present in ductal cancer and
Externí odkaz:
https://doaj.org/article/3cdb33c07bc0424796ec8d86fe1fbf8b
Autor:
Eva Andreuzzi, Albina Fejza, Maurizio Polano, Evelina Poletto, Lucrezia Camicia, Greta Carobolante, Giulia Tarticchio, Federico Todaro, Emma Di Carlo, Melania Scarpa, Marco Scarpa, Alice Paulitti, Alessandra Capuano, Vincenzo Canzonieri, Stefania Maiero, Mara Fornasarig, Renato Cannizzaro, Roberto Doliana, Alfonso Colombatti, Paola Spessotto, Maurizio Mongiat
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-23 (2022)
Abstract Background Colorectal cancer is one of the most frequent and deadly tumors. Among the key regulators of CRC growth and progression, the microenvironment has emerged as a crucial player and as a possible route for the development of new thera
Externí odkaz:
https://doaj.org/article/1ec58e08fd3b4c05a510e0ada40d8d98
Autor:
Emilia Alors-Perez, Ricardo Blázquez-Encinas, Sonia Alcalá, Cristina Viyuela-García, Sergio Pedraza-Arevalo, Vicente Herrero-Aguayo, Juan M. Jiménez-Vacas, Andrea Mafficini, Marina E. Sánchez-Frías, María T. Cano, Fernando Abollo-Jiménez, Juan A. Marín-Sanz, Pablo Cabezas-Sainz, Rita T. Lawlor, Claudio Luchini, Laura Sánchez, Juan M. Sánchez-Hidalgo, Sebastián Ventura, Laura Martin-Hijano, Manuel D. Gahete, Aldo Scarpa, Álvaro Arjona-Sánchez, Alejandro Ibáñez-Costa, Bruno Sainz, Raúl M. Luque, Justo P. Castaño
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-21 (2021)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem cells (CSCs). Altered splicing is emerging as both a novel cancer hallmark and an attractive
Externí odkaz:
https://doaj.org/article/2e57a0d7fd7f42d6a9f88e1c0cae6aca
Autor:
Claudio Luchini, Gaetano Paolino, Paola Mattiolo, Maria L. Piredda, Alessandro Cavaliere, Marina Gaule, Davide Melisi, Roberto Salvia, Giuseppe Malleo, Jae Il Shin, Sarah Cargnin, Salvatore Terrazzino, Rita T. Lawlor, Michele Milella, Aldo Scarpa
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-10 (2020)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, whose main molecular trait is the MAPK pathway activation due to KRAS mutation, which is present in 90% of cases. The genetic landscape of KRAS wild type PDAC can be divided into t
Externí odkaz:
https://doaj.org/article/141ae78135ad4d56af7925eaa8608200
Autor:
Chiara Marchiori, Melania Scarpa, Andromachi Kotsafti, Susan Morgan, Matteo Fassan, Vincenza Guzzardo, Andrea Porzionato, Imerio Angriman, Cesare Ruffolo, Stefania Sut, Stefano Dall’Acqua, Romeo Bardini, Raffaele De Caro, Carlo Castoro, Marco Scarpa, Ignazio Castagliuolo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background One of the most potent costimulatory molecules involved in the recognition and killing of tumor cells is CD80. However, its role and the molecular mechanisms regulating its expression in sporadic colorectal carcinogenesis remain e
Externí odkaz:
https://doaj.org/article/e89f4450d6954c29a710e99a9d9aad08