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Autor:
Tawfiq Arafat, Tareq N. Khamis, Ruba S. Darweesh, Wahby M. Babaresh, Tamam El-Elimat, Ahmed H. Al Sharie, Aref Zayed
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-15 (2020)
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology
BackgroundImatinib is mainly metabolized by CYP3A4 and to a lesser extent by other isoenzymes, withN-desmethyl imatinib being its major equipotent metabolite. Being a CYP3A4 substrate, imatinib co-administration with CYP3A4 modulators would change it
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-10 (2020)
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology
Background The present study aimed to develop and validate a rapid, selective, and reproducible ultra-performance liquid chromatography-tandem mass spectrometry separation method for the simultaneous determination of the levels of parecoxib and its m