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Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-12 (2021)
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology
Background Melittin is one of the most studied antimicrobial peptides, and several in vitro experiments have demonstrated its antibacterial efficacy. However, there is evidence showing melittin has non-promising effects such as cytotoxicity and hemol
Autor:
Kay D. Beharry, Faisal Siddiqui, Charles L Cai, Stephen Wadowski, Jacob V Aranda, Karen Deslouches, Christina D’Agrosa
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-11 (2021)
Respiratory Research
Respiratory Research
Background Neonatal intermittent hypoxia (IH) results in oxidative distress in preterm infants with immature antioxidant systems, contributing to lung injury. Coenzyme Q10 (CoQ10) and fish oil protect against oxidative injury. We tested the hypothesi
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-15 (2021)
Journal of Nanobiotechnology
Journal of Nanobiotechnology
Background One of the greatest challenges for tissue-engineered bone is the low survival rate of locally grafted cells. The cell homing technology can effectively increase the number of these grafted cells, therefore, enhancing the repair of bone def
Autor:
Stein Håkon Låstad Lygre, Hilde Kristin Vindenes, Francisco Gómez Real, Randi Jacobsen Bertelsen, Tamar Ringel-Kulka, Cecilie Svanes
Publikováno v:
Environmental Health, Vol 20, Iss 1, Pp 1-16 (2021)
Environmental health
Environmental Health
Environmental health
Environmental Health
BackgroundMany phenols and parabens are applied in cosmetics, pharmaceuticals and food, to prevent growth of bacteria and fungi. Whether these chemicals affect inflammatory diseases like allergies and overweight is largely unexplored. We aimed to ass
Autor:
Fahri Bayram, Katerina Urbancova, Capture Study Investigators, Abdullah M. Alguwaihes, Shinichiro Shirabe, Csaba Lengyel, Guillermo Dieuzeide, Ofri Mosenzon, Jose Luis A. Leon, Nicolai Rhee, Giuseppina T. Russo, Sergio Vencio, Margit S Kaltoft, Patrice Darmon, Timothy M. E. Davis, Kirsten T. Eriksen, Tianpei Hong
Publikováno v:
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-13 (2021)
Cardiovascular Diabetology
Cardiovascular Diabetology, 2021, 20 (1), pp.154. ⟨10.1186/s12933-021-01344-0⟩
Cardiovascular Diabetology
Cardiovascular Diabetology, 2021, 20 (1), pp.154. ⟨10.1186/s12933-021-01344-0⟩
Background There is a paucity of global data on cardiovascular disease (CVD) prevalence in people with type 2 diabetes (T2D). The primary objective of the CAPTURE study was to estimate the prevalence of established CVD and its management in adults wi
Autor:
Sicheng Liang, Liang Yue, Wenqiao Qiu, Hong Li, Xin Shen, An-Guo Wu, Jing Lin, Jianming Wu, Dalian Qin, Nan Jiang
Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-10 (2021)
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology
Background Abnormally elevated xanthine oxidase (XO) activity has been verified to cause various pathological processes, such as gout, oxidative stress injury and metabolic syndrome. Thus, XO activators may exhibit above potential toxicological prope
Publikováno v:
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-8 (2021)
Cardiovascular Diabetology
Cardiovascular Diabetology
Background Triglyceride–glucose (TyG) index, a simple surrogate marker of insulin resistance, has been reported to be associated with arterial stiffness. However, previous studies were limited by the cross-sectional design. The purpose of this stud
Autor:
Zhibao Mi, Jun-Chieh Tsay, Zachary W Taylor, Sonny Tsai, Daniel Briones, Christina E. Clise, R. Bruce Montgomery, Michelle Geelhoed, Matthew Bidwell Goetz, Leila Ghayouri, Jeffrey R Huminik, Carlie Sulpizio, Rachel Ramoni, Guy W. Soo Hoo, Xinchen Wang, Kousick Biswas, David Goldstein, Nicholas G. Nickols, Danil V. Makarov, Kenute Myrie, Melissa Diamond, Mohammad Al-Ajam, Matthew Rettig, Christopher J. Graber, Debika Bhattacharya, Joseph Tadalan, Matthew Might, Samantha Tran, Asha George, Elahe A. Mostaghel, Leslie E Norman, Pooja Belligund, Daniel J. Becker, Ellen DeMatt
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-8 (2021)
Trials
Trials
Background Therapeutic targeting of host-cell factors required for SARS-CoV-2 entry is an alternative strategy to ameliorate COVID-19 severity. SARS-CoV-2 entry into lung epithelium requires the TMPRSS2 cell surface protease. Pre-clinical and correla
Autor:
Przemyslaw Szafranski, Pawel Stankiewicz, Tomasz Gambin, Jason D. Heaney, Rebecca L. Maywald, Justyna A. Karolak, Edwina J. Popek
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-11 (2021)
Respiratory Research
Respiratory Research
Background Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare lethal congenital lung disorder in neonates characterized by severe progressive respiratory failure and refractory pulmonary hypertension, resulting from
Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-11 (2021)
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology
BackgroundThe present study investigated the ameliorative effect of melittin, a major polypeptide in the venom of honeybee (Apis mellifera), on isoniazid-(INH) and rifampicin-(RIF) induced hepatotoxicity in male albino rats.MethodThirty rats (140-200