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Autor:
Andrey Sivkov, Svetlana Sivkova, Roman V. Gorenkov, Sergey Sivkov, Natalya P. Chernus, Tamara Savina
Publikováno v:
Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-9 (2021)
Lipids in Health and Disease
Lipids in Health and Disease
Background To determine the effect of genetic polymorphism of drug transporters on the efficacy of treatment with Rosuvastatin, Atorvastatin and Simvastatin in patients with hyperlipidemia. Methods The study consists of 180 patients, aged 40–75 yea
Autor:
Jane Kabwe, Hirofumi Sawada, Masako Kawai, Kazuo Maruyama, Ayumu Yokochi, Yoshihide Mitani, Amphone Okada, Ayaka Omori, Toshikazu Ito, Junko Maruyama, Erquan Zhang
Publikováno v:
BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-17 (2021)
BMC Pulmonary Medicine
BMC Pulmonary Medicine
Background Preventing pulmonary vascular remodeling is a key strategy for pulmonary hypertension (PH). Causes of PH include pulmonary vasoconstriction and inflammation. This study aimed to determine whether cilostazol (CLZ), a phosphodiesterase-3 inh
Publikováno v:
Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-5 (2021)
Journal of Medical Case Reports
Journal of Medical Case Reports
Background Massive hemoptysis due to aspergilloma is a rare but life-threatening complication. Bronchial artery embolization is recommended as a definitive treatment for massive hemoptysis. Polyvinyl alcohol is widely used in bronchial artery emboliz
Autor:
Frederic Peyrade, Graham P. Collins, Yihua Lee, Jutta K. Neuenburg, Michael Wang, Robert T. Chen, Geoffrey Chong, Karl Eckert, Constantine S. Tam, Radhakrishnan Ramchandren, Lionel Karlin, Ka Lung Wu, Mark Bishton, Paul Eliadis, Wojciech Jurczak
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-8 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Ibrutinib plus venetoclax, given with an ibrutinib lead-in, has shown encouraging clinical activity in early phase studies in mantle cell lymphoma (MCL). The ongoing phase 3 SYMPATICO study evaluates the safety and efficacy of concurrently administer
Autor:
Huang Tz Ou, Fang Hsiu Kuo, Hsin Ju Tang, Chun Ting Yang, Chia Te Liao, Hung Yu Chang, Carol Strong, Yi Ming Hua, Mei Chuan Lee, Han Siong Toh, Wei Ting Chang
Publikováno v:
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-10 (2021)
Cardiovascular Diabetology
Cardiovascular Diabetology
Background With emerging evidence on the efficacy of adding dapagliflozin to standard care for patients with heart failure with reduced ejection fraction (HFrEF), this study assessed the cost-effectiveness of add-on dapagliflozin to standard care ver
Autor:
Liru He, Yijun Zhang, Dong Chen, Yanjun Wang, Yonghong Li, Jun Wang, Hao Zeng, Yanxia Shi, Fangjian Zhou, Zhenyu Yang, Yuchao Ni, Zhiming Wu, Lijuan Jiang, Diwei Zhao
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
BMC Cancer
BMC Cancer
BackgroundTo assess the efficacies and potential predictors of a corticosteroid switch in metastatic castration-resistant prostate cancer (mCRPC) patients with biochemical progression on abiraterone acetate plus prednisone (A + P).MethodsPatients wit
Autor:
Enock Kizito, Felix Bongomin, Richard Katuramu, Joseph Baruch Baluku, Joshua Naloka, Martin Nabwana
Publikováno v:
BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Pulmonary Medicine
BMC Pulmonary Medicine
Background Patients with drug resistant tuberculosis (DR-TB) with comorbidities and drug toxicities are difficult to treat. Guidelines recommend such patients to be managed in consultation with a multidisciplinary team of experts (the “TB consilium
Autor:
Zhibao Mi, Jun-Chieh Tsay, Zachary W Taylor, Sonny Tsai, Daniel Briones, Christina E. Clise, R. Bruce Montgomery, Michelle Geelhoed, Matthew Bidwell Goetz, Leila Ghayouri, Jeffrey R Huminik, Carlie Sulpizio, Rachel Ramoni, Guy W. Soo Hoo, Xinchen Wang, Kousick Biswas, David Goldstein, Nicholas G. Nickols, Danil V. Makarov, Kenute Myrie, Melissa Diamond, Mohammad Al-Ajam, Matthew Rettig, Christopher J. Graber, Debika Bhattacharya, Joseph Tadalan, Matthew Might, Samantha Tran, Asha George, Elahe A. Mostaghel, Leslie E Norman, Pooja Belligund, Daniel J. Becker, Ellen DeMatt
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-8 (2021)
Trials
Trials
Background Therapeutic targeting of host-cell factors required for SARS-CoV-2 entry is an alternative strategy to ameliorate COVID-19 severity. SARS-CoV-2 entry into lung epithelium requires the TMPRSS2 cell surface protease. Pre-clinical and correla
Autor:
Shuyan Liu, Guoliang Zhang, Yingxia Liu, Juan Meng, Dongqi Wang, Jincheng Chen, Peng Yin, Muchun Zhu, Junxiao Gao, Gengwei Zhang, Ye Li, Qinglong Guo
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-11 (2021)
Virology Journal
Virology Journal
Objectives The aim of this study was to evaluate the role of antiviral drugs in reducing the risk of developing severe illness in patients with moderate COVID-19 pneumonia. Methods This retrospective cohort study included 403 adult patients with mode
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-5 (2021)
BMC Cancer
BMC Cancer
Background Chemotherapy induced nausea- vomiting (CINV) is considered as the most common, feared and most troublesome side effect of chemotherapy. NEPA (NEtupitant 300 mg + PAlonosetron 0.50 mg) is the first commercially available oral fixed-dose com