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Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
BMC Cancer
BMC Cancer
Background Lymph node metastasis (LNM) status is an important prognostic factor that strongly influences the treatment decision of early gastric cancer (EGC). This study aimed to evaluate the pattern and clinical significance of LNM in EGC. Methods A
Autor:
Ke Shi, Jin Zhong Zhang, Ying Yue, Ning-Ning Li, Yu Cheng Lu, Dan Guo, Xiu-Zhi Zhang, Liang Yang, Xiu-Hong Du
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
BMC Cancer
BMC Cancer
Aurora A kinase is a cell cycle regulator that is dysregulated in several different malignancies. Nevertheless, its regulatory mechanisms are still not fully understood. Here, we report that ubiquitin specific peptidase 3 (USP3) promotes proliferatio
Autor:
Hiroko Shindo, Yoshimitsu Fukasawa, Ei Takahashi, Hiroshi Kono, Hiroshi Hayakawa, Hiromichi Kawaida, Nobuyuki Enomoto, Natsuhiko Kuratomi, Shinya Maekawa, Satoshi Kawakami, Shinichi Takano, Hidetake Amemiya, Daisuke Ichikawa, Mitsuharu Fukasawa, Naohiro Hosomura, Makoto Kadokura
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
BMC Cancer
BMC Cancer
Background The genetic changes underlying carcinogenesis in patients with risk factors of gallbladder carcinoma (GBC) remains controversial, especially in patients with pancreaticobiliary maljunction (PBM). This study aimed to clarify the association
Autor:
Sajad Shafiekhani, Azam Sadat Fatemi, Sara Rahbar, Amir Jafari, Jamshid Hadjati, Hojat Dehghanbanadaki
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-21 (2021)
BMC Cancer
BMC Cancer
Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with rising incidence and with 5-years overall survival of less than 8%. PDAC creates an immune-suppressive tumor microenvironment to escape immune-mediated eradication. Re
Autor:
Bing Chen, Jingjing Zhao, Qin Li, Yuchen Li, Qiupeng Zheng, Hongyan Lai, Siyuan Chen, Shenglin Huang, Xiao-Dong Zhu, Yan Li
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-22 (2021)
BMC Cancer
BMC Cancer
Background Viral infections are prevalent in human cancers and they have great diagnostic and theranostic values in clinical practice. Recently, their potential of shaping the tumor immune microenvironment (TIME) has been related to the immunotherapy
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
BMC Cancer
BMC Cancer
Objective Although perineural invasion (PNI) is well-known to be correlated with and able to predict lymph node metastasis (LNM) in oral squamous cell carcinoma (OSCC), the clinical and molecular correlation between PNI and LNM has not been elucidate
Autor:
Junping Liu, Zhenying Guo, Weimin Mao, Yun Gao, Ding Wang, Siyu Song, Chenxi Yang, Zhongjian Chen
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-15 (2021)
BMC Cancer
BMC Cancer
Background Malignant pleural mesothelioma (MPM) is a rare and aggressive carcinoma located in pleural cavity. Due to lack of effective diagnostic biomarkers and therapeutic targets in MPM, the prognosis is extremely poor. Because of difficulties in s
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-15 (2021)
BMC Cancer
BMC Cancer
Background: Lipid metabolic reprogramming was considered as a new hallmark of malignant tumors. It has been reported to play a crucial biological role in cell proliferation, energy homeostasis and signal-transduction. However, the important value of
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
BMC Cancer
BMC Cancer
Background Compared to conventional adenocarcinoma (CA), mucin-producing adenocarcinoma (MPA) is an uncommon histological subtype and is usually separated from other histological types and has been evaluated separately. The objective was to compare t
Autor:
Weiguo Lu, Xiaoyun Wan, Liya Dong, Yizhen Niu, Xiaofei Zhang, Lina Yu, Feng Zhou, Lili Chen, Amanda L. Strickland
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
BMC Cancer
BMC Cancer
Background We aimed to analyze the clinicopathological features and outcomes of patients with gastric-type of HPV-independent endocervical adenocarcinoma (GAS HPVI ECA), and compare them with non-GAS HPVI ECA cases. Methods Thirty-eight GASs [includi