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Autor:
Benedetto Bruno, Yubao Wang, Hussein Ghamlouch, Brian A Walker, Michael A Bauer, Faith E. Davies, Patrick Blaney, Louis Williams, Eileen M Boyle, Daniel Auclair, Jinyoung Choi, Gareth J. Morgan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-23 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Despite improvements in outcome, 15-25% of newly diagnosed multiple myeloma (MM) patients have treatment resistant high-risk (HR) disease with a poor survival. The lack of a genetic basis for HR has focused attention on the role played by epigenetic
Autor:
Chiara Giacomelli, Astrid Wachter, Stefan Wiemann, Jung J, Yosef Yarden, Cindy Körner, Ozgur Sahin, Stefan Uhlmann, Rainer Will, Ulrike Korf, Ibing S, Tim Beißbarth, Heiko Mannsperger
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-19 (2021)
BMC Cancer
BMC Cancer
Background Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC). Treatment options for TNBC patients are limited and further insights into disease aetiology are needed to develop better therapeutic approaches. mic
Autor:
Ke Shi, Jin Zhong Zhang, Ying Yue, Ning-Ning Li, Yu Cheng Lu, Dan Guo, Xiu-Zhi Zhang, Liang Yang, Xiu-Hong Du
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
BMC Cancer
BMC Cancer
Aurora A kinase is a cell cycle regulator that is dysregulated in several different malignancies. Nevertheless, its regulatory mechanisms are still not fully understood. Here, we report that ubiquitin specific peptidase 3 (USP3) promotes proliferatio
Autor:
Xiamei Guo, Li Zhang, Fei Xie, Cheng Shen, Chao Luo, Yali Jun, Keping Xu, Qilong Wang, Xiaojuan Yu, Zhengwei Zhang, Longfei Liu, Yong Gao, Xiang Li
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-16 (2021)
Journal of Nanobiotechnology
Journal of Nanobiotechnology
Background Esophageal cancer is the fifth most common cancer affecting men in China. The primary treatment options are surgery and traditional radio-chemotherapy; no effective targeted therapy exists yet. Self-assembled RNA nanocarriers are highly st
Autor:
Lili Feng, Yi Chang, Ying Chu, Shengjun Wang, Wei Lu, Fenghua Cao, Bo Shen, Ge Song, Zhihong Chen, Huaxi Xu, Jie Ma
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-4 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Myeloid-derived suppressor cells (MDSCs) are derived from bone marrow progenitor cells commonly, which is a heterogeneous cell group composed of immature granulocytes, dendritic cells, macrophages and early undifferentiated bone marrow precursor cell
Autor:
Jonathan D. Leavenworth, Michael L. Dixon, Sadashib Ghosh, Lin Luo, Jeffrey M. Grimes, Jianmei W. Leavenworth
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-24 (2021)
Background Accumulation of Foxp3+ regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an
Autor:
Mayank Singh, Ravi Chauhan, Mohammad Haris, Tariq Masoodi, Ravinder Reddy, Ashna Gupta, Zahoor Ahmad Sheikh, Muzafar A. Macha, Ajaz A. Bhat, Puneet Bagga
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ubiquitination process may lead to t
Publikováno v:
World Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-12 (2021)
World Journal of Surgical Oncology
World Journal of Surgical Oncology
Background Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites (SRMS) is a non-receptor tyrosine kinase that has been found to be overexpressed in various tumors. However, the role of SRMS in colorectal cance
Autor:
Wen-Zhao Zhong, Jian Su, Hai-Yan Tu, Hao Sun, Jin-Ji Yang, Guang-Ling Jie, Jia-Tao Zhang, Mei-Mei Zheng, Lun-Xi Peng, Si-Yang Liu, Jia-Ying Zhou, Yi-Long Wu, Qing Zhou, An-Na Li, Hong-Hong Yan, Xu-Chao Zhang
Publikováno v:
Experimental Hematology & Oncology, Vol 10, Iss 1, Pp 1-7 (2021)
Experimental Hematology & Oncology
Experimental Hematology & Oncology
BackgroundMETamplification plays an important role in the development of non-small-cell lung cancer (NSCLC) either de novo or in resistance to epidermal growth factor receptor tyrosine–kinase inhibitor (EGFR-TKI) settings. Fluorescence in situ hybr
Publikováno v:
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-13 (2021)
Journal of Ovarian Research
Journal of Ovarian Research
Background Small nucleolar RNA host gene 25 (SNHG25), a long noncoding RNA, has been well-studied in epithelial ovarian cancer. However, the specific functions of SNHG25 in endometrial cancer (EC) have not been studied yet. In this study, we aimed to