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Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Background The mutational profile of cancer reflects the activity of the mutagenic processes which have been operative throughout the lineage of the cancer cell. These processes leave characteristic profiles of somatic mutations called mutational sig
Autor:
Ruihong Bai, Zhixiang Zuo, Dongxin Lin, Junge Deng, Xudong Huang, Ling Pan, Rufu Chen, Shuang Deng, Jian Zheng, Weiyi Feng, Kaiyu Zhu, Lisha Zhuang, Jiachun Su, Lusheng Wei, Rui Li, Ying Ye, Mei Li, Yanfen Zheng, Jialiang Zhang
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-19 (2021)
Background N6-methyladenosine (m6A) is the most abundant modification of RNA in eukaryotic cells and play critical roles in cancer. While most related studies focus on m6A modifications in linear RNA, transcriptome-wide profiling and exploration of m
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-17 (2021)
Cancer Cell International
Cancer Cell International
Background IL-6 plays a pivotal role in resistance to chemotherapeutics, including lobaplatin. However, the underlying mechanisms are still unclear. This study was to investigate the changes in phosphoproteins and their related signaling pathways in
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-14 (2021)
Molecular Medicine
Molecular Medicine
BackgroundThe FOXP3/miR-146a/NF-κB axis was previously reported to modulate the induction and function of CD4+ Treg cells to alleviate oral lichen planus. Also, other signaling pathways including microRNA-155-IFN-γ loop and FOXP3/miR-146a/TRAF6 pat
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-10 (2021)
Molecular Medicine
Molecular Medicine
Background Acute myeloid leukemia (AML) is a malignancy commonly seen in adults. Previous studies indicated that TRIM14 played a tumorigenic role in various types of cancer and miR-23b-5p was down-regulated in human mesenchymal stem cell-derived exos
Publikováno v:
Molecular Cytogenetics, Vol 14, Iss 1, Pp 1-17 (2021)
Molecular Cytogenetics
Biochemistry Publications
Molecular Cytogenetics
Biochemistry Publications
BackgroundDuring mitosis, chromatin engages in a dynamic cycle of condensation and decondensation. Condensation into distinct units to ensure high fidelity segregation is followed by rapid and reproducible decondensation to produce functional daughte
Autor:
Yiong-Huak Chan, Taotao Sheng, Chukwuemeka George Anene-Nzelu, Mohana Ray, Shamaine Wei Ting Ho, Roger Foo, Kie Kyon Huang, Wen Fong Ooi, Milad Razavi-Mohseni, Kevin P. White, Anders Jacobsen Skanderup, Ngak Leng Sim, Mei Mei Chang, Angie Lay Keng Tan, Sudhakar Jha, Patrick Tan, Nisha Padmanabhan, Chang Xu, Yu Amanda Guo, Manjie Xing, Lijia Ma, Raghav Sundar, Michael A. Beer, Xuewen Ong
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-25 (2021)
Genome Medicine
Genome Medicine
Background Enhancers are distal cis-regulatory elements required for cell-specific gene expression and cell fate determination. In cancer, enhancer variation has been proposed as a major cause of inter-patient heterogeneity—however, most predicted
Autor:
Wei Wang, Yi-Ling Luo, Fan Bai, Li-Yun Huang, Chao Zhang, Shang-Xin Liu, Bin-liu Liu, Weiwei Zhai, Shu-Qiang Yuan, Y Y Zhao, Yang Liu, Zhanghua Chen, Yongming Chen, Jing-Ping Yun, Xi-Xi Chen, Shu-Mei Yan, Yao Liang, Hui-Zhong Zhang, Dazhi Xu, Miao Xu, Mu Sheng Zeng, Qi Zhang, Tian-Liang Xia, Qian Zhong
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-22 (2021)
Genome Medicine
Genome Medicine
Background Epstein-Barr virus (EBV)-associated gastric carcinomas (EBVaGCs) present unique molecular signatures, but the tumorigenesis of EBVaGCs and the role EBV plays during this process remain poorly understood. Methods We applied whole-exome sequ
Autor:
Hanlee P. Ji, Lan Zhao, Susan M. Grimes, Stephanie U. Greer, Carlos Suárez, Erik S. Hopmans, Alison Almeda, GiWon Shin, Hojoon Lee, Laura Miotke, Sigurdis Haraldsdottir
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-18 (2021)
Genome Medicine
Genome Medicine
Colorectal carcinomas (CRCs) which have lost DNA mismatch repair display hypermutability evident in a molecular phenotype called microsatellite instability (MSI). These mismatch repair deficient tumors are thought to lack widespread genomic instabili
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-4 (2021)
Molecular Brain
Molecular Brain
The CACNA1H gene encodes the α1 subunit of the low voltage-activated Cav3.2 T-type calcium channel, an important regulator of neuronal excitability. Alternative mRNA splicing can generate multiple channel variants with distinct biophysical propertie