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Publikováno v:
BMC Anesthesiology, Vol 21, Iss 1, Pp 1-12 (2021)
BMC Anesthesiology
BMC Anesthesiology
Background To determine the hypnotic and analgesic effects of brimonidine, and evaluate its efficacy and safety for general anesthesia. Potentiation of pentobarbital sleeping time following brimonidine administration was observed in mice, as was the
Autor:
Huili Zheng, Hu Chen, Yesi Shi, Yang Zhang, Pan He, Gan Lin, Zhongning Lin, Zhixiang Lu, Chao Liu, Gang Liu, Dan Mu
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-17 (2021)
Journal of Nanobiotechnology
Journal of Nanobiotechnology
Background Autophagy is a conserved catabolic process, which plays an important role in regulating tumor cell motility and degrading protein aggregates. Chemotherapy-induced autophagy may lead to tumor distant metastasis and even chemo-insensitivity
Autor:
L. Cavalcante, R. Perret, Valérie Velasco, F. Giles, Vanessa Chaire, Antoine Italiano, Stéphanie Verbeke, Elodie Richard
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-5 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Soft tissue sarcoma (STS) is a predominantly fatal rare malignancy with inadequate treatment options. Glycogen synthase kinase 3β (GSK-3β) is an emerging target in human malignancies. Its therapeutic relevance in STS is unknown. We analyzed the pro
Autor:
Ernesto P. Molmenti, Santiago J. Miyara, Junichi Sasaki, Koichiro Shinozaki, Tai Yin, Muhammad Shoaib, Shuhei Eguchi, Kentaro Oka, Kei Hayashida, Daniel M Rolston, Mitsuaki Nishikimi, Motomichi Takahashi, Koichiro Homma, Tomoaki Aoki, Rishabh C. Choudhary, Ryosuke Takegawa, Lance B Becker, Tadashi Ariyoshi, Asami Matsumoto, Yusuke Endo, Junhwan Kim
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-12 (2021)
Journal of Translational Medicine
Journal of Translational Medicine
Background Despite the benefits of extracorporeal cardiopulmonary resuscitation (ECPR) in cohorts of selected patients with cardiac arrest (CA), extracorporeal membrane oxygenation (ECMO) includes an artificial oxygenation membrane and circuits that
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Bone formation plays an important role in early tendon–bone healing after anterior cruciate ligament reconstruction (ACLR). Dedifferentiated osteogenic bone marrow mesenchymal stem cells (De-BMSCs) have enhanced osteogenic potential. Thi
Autor:
Xiamei Guo, Li Zhang, Fei Xie, Cheng Shen, Chao Luo, Yali Jun, Keping Xu, Qilong Wang, Xiaojuan Yu, Zhengwei Zhang, Longfei Liu, Yong Gao, Xiang Li
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-16 (2021)
Journal of Nanobiotechnology
Journal of Nanobiotechnology
Background Esophageal cancer is the fifth most common cancer affecting men in China. The primary treatment options are surgery and traditional radio-chemotherapy; no effective targeted therapy exists yet. Self-assembled RNA nanocarriers are highly st
Autor:
Lili Feng, Yi Chang, Ying Chu, Shengjun Wang, Wei Lu, Fenghua Cao, Bo Shen, Ge Song, Zhihong Chen, Huaxi Xu, Jie Ma
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-4 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Myeloid-derived suppressor cells (MDSCs) are derived from bone marrow progenitor cells commonly, which is a heterogeneous cell group composed of immature granulocytes, dendritic cells, macrophages and early undifferentiated bone marrow precursor cell
Autor:
Youzhen Ge, Weidong Zhang, Xiang Chen, Tianyun Feng, Cheng Yi, Minfeng Gan, Cenhao Wu, Xiaojing Xu, Lixiang Zhao, Jun Zou, Mengjie Liu
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-15 (2021)
Journal of Nanobiotechnology
Journal of Nanobiotechnology
Abstarct Background Cytosine-phosphate-guanine (CpG) dinucleotides has been used as adjuvants for cancer immunotherapy. However, unmodified CpG are not very efficient in clinical trials. Glucose, ligand of C-type lectin receptors (CLRs), can promote
Autor:
Jos Boekhorst, Jori Fuhren, Christiane Rösch, Michiel Kleerebezem, Henk A. Schols, Markus Schwalbe
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-17 (2021)
Microbiome 9 (2021)
Microbiome, 9
Microbiome
Microbiome 9 (2021)
Microbiome, 9
Microbiome
Background Fructo-oligosaccharides (FOS), inulin, and galacto-oligosaccharides (GOS) are widely recognized prebiotics that profoundly affect the intestinal microbiota, including stimulation of bifidobacteria and lactobacilli, and are reported to elic
Autor:
Tomoyuki Nakagiri, Fabio Ius, Ann-Kathrin Knöfel, Tobias Goecke, Patrick Zardo, Tobias Welte, Sabine Wrenger, Veronika Grau, Kokilavani Sivaraman, Axel Haverich, Sabina Janciauskiene
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-12 (2021)
Respiratory Research
Respiratory Research
Background α1-Antitrypsin (AAT) is an acute phase glycoprotein, a multifunctional protein with proteinase inhibitory, anti-inflammatory and cytoprotective properties. Both preclinical and clinical experiences show that the therapy with plasma purifi