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Autor:
Se Kyu Oh, Chang-Duk Jun, Fatima Yasmin, Chang-Hyun Kim, Ik-Joo Chung, Jeong-Su Park, Hyeran Kim, Jin-Hwa Park
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-23 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Background Transgelin-2 is a 22 kDa actin-binding protein that has been proposed to act as an oncogenic factor, capable of contributing to tumorigenesis in a wide range of human malignancies. However, little is known whether this tiny protein also pl
Autor:
Hongtao Liu
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-20 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Until recently, acute myeloid leukemia (AML) patients used to have limited treatment options, depending solely on cytarabine + anthracycline (7 + 3) intensive chemotherapy and hypomethylating agents. Allogeneic stem cell transplantation (Allo-SCT) pl
Autor:
Zhipeng Li, Tianli Chen, Rongqi Sun, Yunfei Xu, Jialiang Liu, Zongli Zhang, Zengli Liu, Bo Qiu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Cholangiocarcinoma is a highly malignant cancer with very dismal prognosis. Perihilar cholangiocarcinoma(pCCA) accounts for more than 50% of all cholangiocarcinoma and is well-characterized for its low rate of radical resection. Effects of
Autor:
Wendy V. Ingman, Leigh J. Hodson, Lucy Woolford, Danielle J. Glynn, Sarah A. Robertson, Sarah M. Bernhardt, Cong Yan, Andreas Evdokiou, Hong Du, Xuan Sun
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-16 (2021)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
BackgroundTransforming growth factor beta1 (TGFB1) is a multi-functional cytokine that regulates mammary gland development and cancer progression through endocrine, paracrine and autocrine mechanisms. TGFB1 also plays roles in tumour development and
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-29 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
The immune system is the core defense against cancer development and progression. Failure of the immune system to recognize and eliminate malignant cells plays an important role in the pathogenesis of cancer. Tumor cells evade immune recognition, in
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-11 (2021)
Radiation Oncology (London, England)
Radiation Oncology (London, England)
Radiation nephropathy (RN) is a kidney injury induced by ionizing radiation. In a clinical setting, ionizing radiation is used in radiotherapy (RT). The use and the intensity of radiation therapy is limited by normal-tissue damage including kidney to
Autor:
Mengke Niu, Suxia Luo, Ying Jiao, Jing Zhang, Anping Li, Yongxiang Yan, Kongming Wu, Pengfei Zhou, Ming Yi
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-22 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Background Therapeutic antibodies targeting programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) axis induce potent and durable anti-tumor responses in multiple types of cancers. However, only a subset of patients benefits from an
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-11 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Less than a year since the start of the COVID-19 pandemic, ten vaccines against SARS-CoV-2 have been approved for at least limited use, with over sixty others in clinical trials. This swift achievement has generated excitement and arrives at a time o
Autor:
Shengnan Zhang, Qing Yang, Xin Fang, Barbara Seliger, Heng Liang, Chunxiang Kuang, Lei Shi, Yu Yao, Zikang Xing
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Indoleamine 2,3-dioxygenase 1 (IDO1), a monomeric heme-containing enzyme, catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan metabolism, which plays an important role in immunity and neuronal function. Its implication
Autor:
Elisabetta Falvo, Federico Boschi, Verena Damiani, Veronica Morea, Michele Milella, Gianluca Sala, Giulio Fracasso, Pierpaolo Ceci, Giamaica Conti, Katia Messana, Patrizio Giacomini, Vincenzo De Laurenzi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)
Journal of experimental & clinical cancer research (Online) 40 (2021). doi:10.1186/s13046-021-01851-8
info:cnr-pdr/source/autori:Falvo, Elisabetta; Damiani, Verena; Conti, Giamaica; Boschi, Federico; Messana, Katia; Giacomini, Patrizio; Milella, Michele; De Laurenzi, Vincenzo; Morea, Veronica; Sala, Gianluca; Fracasso, Giulio; Ceci, Pierpaolo/titolo:High activity and low toxicity of a novel CD71-targeting nanotherapeutic named The-0504 on preclinical models of several human aggressive tumors/doi:10.1186%2Fs13046-021-01851-8/rivista:Journal of experimental & clinical cancer research (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:40
Journal of Experimental & Clinical Cancer Research : CR
Journal of experimental & clinical cancer research (Online) 40 (2021). doi:10.1186/s13046-021-01851-8
info:cnr-pdr/source/autori:Falvo, Elisabetta; Damiani, Verena; Conti, Giamaica; Boschi, Federico; Messana, Katia; Giacomini, Patrizio; Milella, Michele; De Laurenzi, Vincenzo; Morea, Veronica; Sala, Gianluca; Fracasso, Giulio; Ceci, Pierpaolo/titolo:High activity and low toxicity of a novel CD71-targeting nanotherapeutic named The-0504 on preclinical models of several human aggressive tumors/doi:10.1186%2Fs13046-021-01851-8/rivista:Journal of experimental & clinical cancer research (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:40
Journal of Experimental & Clinical Cancer Research : CR
Background Ferritin receptor (CD71) is an example of a very attractive cancer target, since it is highly expressed in virtually all tumor types, including metastatic loci. However, this target can be considered to be inaccessible to conventional targ