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Autor:
Se Kyu Oh, Chang-Duk Jun, Fatima Yasmin, Chang-Hyun Kim, Ik-Joo Chung, Jeong-Su Park, Hyeran Kim, Jin-Hwa Park
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-23 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Background Transgelin-2 is a 22 kDa actin-binding protein that has been proposed to act as an oncogenic factor, capable of contributing to tumorigenesis in a wide range of human malignancies. However, little is known whether this tiny protein also pl
Autor:
Zhipeng Li, Tianli Chen, Rongqi Sun, Yunfei Xu, Jialiang Liu, Zongli Zhang, Zengli Liu, Bo Qiu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Cholangiocarcinoma is a highly malignant cancer with very dismal prognosis. Perihilar cholangiocarcinoma(pCCA) accounts for more than 50% of all cholangiocarcinoma and is well-characterized for its low rate of radical resection. Effects of
Autor:
Wendy V. Ingman, Leigh J. Hodson, Lucy Woolford, Danielle J. Glynn, Sarah A. Robertson, Sarah M. Bernhardt, Cong Yan, Andreas Evdokiou, Hong Du, Xuan Sun
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-16 (2021)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
BackgroundTransforming growth factor beta1 (TGFB1) is a multi-functional cytokine that regulates mammary gland development and cancer progression through endocrine, paracrine and autocrine mechanisms. TGFB1 also plays roles in tumour development and
Autor:
Mengke Niu, Suxia Luo, Ying Jiao, Jing Zhang, Anping Li, Yongxiang Yan, Kongming Wu, Pengfei Zhou, Ming Yi
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-22 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Background Therapeutic antibodies targeting programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) axis induce potent and durable anti-tumor responses in multiple types of cancers. However, only a subset of patients benefits from an
Autor:
Shengnan Zhang, Qing Yang, Xin Fang, Barbara Seliger, Heng Liang, Chunxiang Kuang, Lei Shi, Yu Yao, Zikang Xing
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Indoleamine 2,3-dioxygenase 1 (IDO1), a monomeric heme-containing enzyme, catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan metabolism, which plays an important role in immunity and neuronal function. Its implication
Autor:
Elisabetta Falvo, Federico Boschi, Verena Damiani, Veronica Morea, Michele Milella, Gianluca Sala, Giulio Fracasso, Pierpaolo Ceci, Giamaica Conti, Katia Messana, Patrizio Giacomini, Vincenzo De Laurenzi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)
Journal of experimental & clinical cancer research (Online) 40 (2021). doi:10.1186/s13046-021-01851-8
info:cnr-pdr/source/autori:Falvo, Elisabetta; Damiani, Verena; Conti, Giamaica; Boschi, Federico; Messana, Katia; Giacomini, Patrizio; Milella, Michele; De Laurenzi, Vincenzo; Morea, Veronica; Sala, Gianluca; Fracasso, Giulio; Ceci, Pierpaolo/titolo:High activity and low toxicity of a novel CD71-targeting nanotherapeutic named The-0504 on preclinical models of several human aggressive tumors/doi:10.1186%2Fs13046-021-01851-8/rivista:Journal of experimental & clinical cancer research (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:40
Journal of Experimental & Clinical Cancer Research : CR
Journal of experimental & clinical cancer research (Online) 40 (2021). doi:10.1186/s13046-021-01851-8
info:cnr-pdr/source/autori:Falvo, Elisabetta; Damiani, Verena; Conti, Giamaica; Boschi, Federico; Messana, Katia; Giacomini, Patrizio; Milella, Michele; De Laurenzi, Vincenzo; Morea, Veronica; Sala, Gianluca; Fracasso, Giulio; Ceci, Pierpaolo/titolo:High activity and low toxicity of a novel CD71-targeting nanotherapeutic named The-0504 on preclinical models of several human aggressive tumors/doi:10.1186%2Fs13046-021-01851-8/rivista:Journal of experimental & clinical cancer research (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:40
Journal of Experimental & Clinical Cancer Research : CR
Background Ferritin receptor (CD71) is an example of a very attractive cancer target, since it is highly expressed in virtually all tumor types, including metastatic loci. However, this target can be considered to be inaccessible to conventional targ
Autor:
Martha M. Grimes, Yuna Guo, Dayna Dominguez, Laurie G. Hudson, Angela Wandinger-Ness, Kathryn J. Brayer, S. Ray Kenney
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-16 (2021)
BMC Cancer
BMC Cancer
Background Rho-family GTPases, including Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division control protein 42 (Cdc42), are important modulators of cancer-relevant cell functions and are viewed as promising therapeutic targets. Based
Autor:
Wenli Fang, Mengli Yao, Chengsen Chai, He Shi, Qian Zeng, Yange Wang, Fangfang Jin, Husun Qian, Ting Zhou, Dian Zhang, Tingmei Chen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-11 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the effect of PGRN on breast cancer tumor immunity and its possible mole
Autor:
Yaxin Guo, Qin Dang, Guixian Wang, Qisan Wang, Chen Chen, Quanbo Zhou, Zhenqiang Sun, Weitang Yuan, Jinbo Liu, Xiaoli Li, Quancheng Kan, Bo Shao, Qiuge Zhang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-16 (2020)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Glycolysis plays an essential role in the growth and metastasis of solid cancer and has received increasing attention in recent years. However, the complex regulatory mechanisms of tumour glycolysis remain elusive. This study aimed to expl
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
BMC Cancer
BMC Cancer
Background The effect of brachytherapy on lymphocytes and cytokines in the tumor microenvironment is unclear. This study aimed to analyze the relationship between the invasion of lymphocytes and cytokines in the tumor microenvironment and the interva