Zobrazeno 1 - 10
of 19
pro vyhledávání: ''
Autor:
Shengnan Zhang, Qing Yang, Xin Fang, Barbara Seliger, Heng Liang, Chunxiang Kuang, Lei Shi, Yu Yao, Zikang Xing
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Indoleamine 2,3-dioxygenase 1 (IDO1), a monomeric heme-containing enzyme, catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan metabolism, which plays an important role in immunity and neuronal function. Its implication
Autor:
Yaxin Guo, Qin Dang, Guixian Wang, Qisan Wang, Chen Chen, Quanbo Zhou, Zhenqiang Sun, Weitang Yuan, Jinbo Liu, Xiaoli Li, Quancheng Kan, Bo Shao, Qiuge Zhang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-16 (2020)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Glycolysis plays an essential role in the growth and metastasis of solid cancer and has received increasing attention in recent years. However, the complex regulatory mechanisms of tumour glycolysis remain elusive. This study aimed to expl
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
BMC Cancer
BMC Cancer
Background The effect of brachytherapy on lymphocytes and cytokines in the tumor microenvironment is unclear. This study aimed to analyze the relationship between the invasion of lymphocytes and cytokines in the tumor microenvironment and the interva
Autor:
Abeer A. Almiman, Julian Ramelow, Christopher Brooks, Miguel A. Villalona-Calero, Terence M. Williams, Wenrui Duan, Li Gao
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Cancer
BMC Cancer
Background Lung cancer is the number one cancer killer worldwide. A major drawback in the lung cancer treatment field is the lack of realistic mouse models that replicate the complexity of human malignancy and immune contexture within the tumor micro
Autor:
Jie Chen, Zhidi Pan, Yueqing Xie, Yuexian Zhou, Lei Han, Baohong Zhang, John Gilly, Rui Sun, Huifang Zong, Jianwei Zhu, Huili Lu, Hua Jiang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-14 (2020)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor effic
Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cells
Autor:
Shantibhusan Senapati, Biswajit Das
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-18 (2019)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background In the era of personalized therapy, functional annotation of less frequent genetic aberrations will be instrumental in adapting effective therapeutic in clinic. Overexpression of Melanoma associated antigen A3 (MAGEA3) is reported in certa
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-11 (2019)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Despite major scientific discoveries and novel therapies over the past four decades, the treatment outcomes of acute myeloid leukemia (AML), especially in the adult patient population remain dismal. In the past few years, an increasing number of targ
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
BMC Cancer
BMC Cancer
Background Different strains of Newcastle disease virus (NDV) worldwide proved to have tumouricidal activity in several types of cancer cells. However, the possible anti-cancer activity of Malaysian NDV AF2240 strain and its mechanism of action remai
Autor:
Daniel Davila-Gonzalez, Roberto R. Rosato, Anthony J. Kozielski, Dong Soon Choi, Wei Qian, Jenny C. Chang, Wen Chen, Bhuvanesh Dave, Helen Wong
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-16 (2018)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Background Breast cancer has been considered not highly immunogenic, and few patients benefit from current immunotherapies. However, new strategies are aimed at changing this paradigm. In the present study, we examined the in vivo activity of a human
Autor:
Asunción Martín-Ruiz, Laura Peña, J. C. Illera, Sara Caceres, A. González-Gil, Lucía Teresa Díez-Córdova
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
BMC Cancer
BMC Cancer
Background Indole-3-carbinol, derived from Cruciferous vegetables is an estrogen receptor antagonist considered a preventive agent that is naturally present in diet. There are no previous studies on its effects in human inflammatory breast cancer or