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Autor:
Chiara Giacomelli, Astrid Wachter, Stefan Wiemann, Jung J, Yosef Yarden, Cindy Körner, Ozgur Sahin, Stefan Uhlmann, Rainer Will, Ulrike Korf, Ibing S, Tim Beißbarth, Heiko Mannsperger
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-19 (2021)
BMC Cancer
BMC Cancer
Background Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC). Treatment options for TNBC patients are limited and further insights into disease aetiology are needed to develop better therapeutic approaches. mic
Autor:
Yupei Zhao, Yuan Chen, Chengcheng Wang, Gang Yang, Ruiyuan Xu, Taiping Zhang, Huanyu Wang, Lei You, Xuning Fan, Bo Ren, Jinshou Yang
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-19 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Background Pancreatic cancer’s poor prognosis is caused by distal metastasis, which is associated with epigenetic changes. However, the role of the 3D epigenome in pancreatic cancer biology, especially its metastasis, remains unclear. Methods Here,
Autor:
Long Zhang, Jun Xie, Yufu Zhu, Lansheng Wang, Xuyang Huang, Hongmei Liu, Jun Jia, Yongkang Zhang, Gang Zhao, Naveena Konduru, Rutong Yu
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-14 (2021)
Journal of Nanobiotechnology
Journal of Nanobiotechnology
Background The postoperative recurrence of malignant gliomas has presented a clinical conundrum currently. Worse, there is no standard treatment for these recurrent tumours. Therefore, novel promising methods of clinical treatment are urgently needed
Autor:
Siwen Liu, Jingjing Li, Lulu Cai, Xuan Sha, Yong Wang, Mingming Zhao, Qi Wang, Xiaoxi Song, Yue Dai, Kai Xu
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-17 (2021)
Journal of Nanobiotechnology
Journal of Nanobiotechnology
Background Rupture of atherosclerotic plaque can cause acute malignant heart and cerebrovascular events, such as acute coronary heart disease, stroke and so on, which seriously threaten the safety of human life and property. Therefore, the early diag
Autor:
Aqsa Qambrani, Sana Shaikh, Fawad Ur Rehman, Mohd Ahmar Rauf, Pir Muhammad, Sumaira Hanif, Sajjad Ullah
Publikováno v:
Cancer Nanotechnology, Vol 12, Iss 1, Pp 1-17 (2021)
Background Glioblastoma multiforme (GBM) is one of the most daunting issues to modern therapeutics, with a higher mortality rate post-diagnosis. Temozolomide (TMZ) is the only available treatment; however, the frequent resistance leaves the oncologis
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-9 (2021)
Cancer Cell International
Cancer Cell International
Objective To study the relationship between DNA double-strand break (DSB) repair gene mutations and the risk of papillary thyroid microcarcinoma (PTMC). Methods One hundred patients with PTMC or benign thyroid nodules (BTNs) at Henan Cancer Hospital
Autor:
Jin Xie, Shuyue Zhan, Wei Yang, Yong Teng, Shiyi Zhou, Weizhong Zhang, Zhengwei Cao, Anil Kumar, Wen Jiang, Rui Liu, Xueyuan Yang
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-11 (2021)
Journal of Nanobiotechnology
Journal of Nanobiotechnology
Background Photodynamic therapy (PDT) may elicit antitumor immune response in addition to killing cancer cells. However, PDT as a monotherapy often fails to induce a strong immunity. Immune checkpoint inhibitors, which selectively block regulatory ax
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-8 (2021)
Cancer Cell International
Cancer Cell International
Background Tumor-infiltrating B lymphocytes (TIL-Bs) is a heterogeneous population of lymphocytes. The prognostic value of TIL-Bs in patients with breast cancer remains controversial. Here we conducted this meta-analysis to clarify the association of
Autor:
Jiejing Chen, Jun Zhou, Donge Tang, Ming Yang, Zhiyang Hu, Hua Lin, Wanxia Cai, Xiaofen Qiu, Wen Xue, Qiang Yan, Hongwei Wu, Yong Dai, Haiyan Yu, Weier Dai
Publikováno v:
Human Genomics, Vol 15, Iss 1, Pp 1-13 (2021)
Human Genomics
Human Genomics
Background Trisomy 18 syndrome (Edwards syndrome, ES) is a type of aneuploidy caused by the presence of an extra chromosome 18. Aneuploidy is the leading cause of early pregnancy loss, intellectual disability, and multiple congenital anomalies. The r
Publikováno v:
Cancer Nanotechnology, Vol 12, Iss 1, Pp 1-20 (2021)
Background Brain metastases from non-small cell lung cancer (NSCLC) remain one of the most challenging malignancies. Afatinib (Afa) is an orally administered irreversible ErbB family blocker approved for epidermal growth factor receptor (EGFR)-mutate