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Autor:
Rozario, Ashley M., Duwé, Sam, Elliott, Cade, Hargreaves, Riley B., Moseley, Gregory W., Dedecker, Peter, Whelan, Donna R., Bell, Toby D. M.
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-16 (2021)
BMC Biology
BMC Biology
Background The integrity of microtubule filament networks is essential for the roles in diverse cellular functions, and disruption of its structure or dynamics has been explored as a therapeutic approach to tackle diseases such as cancer. Microtubule
Autor:
Michel Tauc, Marc Cougnon, Romain Carcy, Nicolas Melis, Thierry Hauet, Luc Pellerin, Nicolas Blondeau, Didier F. Pisani
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-23 (2021)
Cell & Bioscience
Cell & Bioscience, BioMed Central, 2021, 11 (1), ⟨10.1186/s13578-021-00733-y⟩
Cell & Bioscience
Cell & Bioscience, BioMed Central, 2021, 11 (1), ⟨10.1186/s13578-021-00733-y⟩
Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor 5A (eIF5A) has been studied principally in relation to the development and progression of cancers in which the isoform A2 is mainly expressed. However,
Autor:
Chiara Giacomelli, Astrid Wachter, Stefan Wiemann, Jung J, Yosef Yarden, Cindy Körner, Ozgur Sahin, Stefan Uhlmann, Rainer Will, Ulrike Korf, Ibing S, Tim Beißbarth, Heiko Mannsperger
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-19 (2021)
BMC Cancer
BMC Cancer
Background Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC). Treatment options for TNBC patients are limited and further insights into disease aetiology are needed to develop better therapeutic approaches. mic
Autor:
Brenda Udosen, Opeyemi Soremekun, Chinwe Ekenna, Olaposi Idowu Omotuyi, Tinashe Chikowore, Oyekanmi Nashiru, Segun Fatumo
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-6 (2021)
BMC Research Notes
BMC Research Notes
Objective The Angiotensin 1 converting enzyme (ACE1) gene plays a critical role in regulating blood pressure and thus, it has become a major therapeutic target of antihypertensives. Single nucleotide polymorphisms (SNPs) occurring within a gene most
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-10 (2021)
Journal of Translational Medicine
Journal of Translational Medicine
Background Translational research is an ideology focussed on streamlining the transition of novel research into clinical practice to ultimately benefit populations. Central to this approach is overcoming barriers to research involvement and interdisc
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-9 (2021)
BMC Medical Genomics
BMC Medical Genomics
Background Incidence of testicular cancer is highest among young adults and has been increasing dramatically for men born since 1945. This study aimed to elucidate the factors driving this trend by investigating differences in mutational signatures b
Publikováno v:
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-12 (2021)
Journal of Ovarian Research
Journal of Ovarian Research
Background Investigate the impact of interval cytoreductive surgery (ICS) on progression in an orthotopic mouse model of ovarian cancer and the impact of chemotherapy delivered at various timelines following surgery. Methods Luciferase-expressing ID8
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-14 (2021)
Genome Biology
Genome Biology
High-throughput single-cell technologies hold the promise of discovering novel cellular relationships with disease. However, analytical workflows constructed for these technologies to associate cell proportions with disease often employ unsupervised
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Cancer
BMC Cancer
Background Malignant pleural mesothelioma (MPM) is a rare but fatal cancer, which is largely caused by exposure to asbestos. Reliable information about the incidence of MPM prior the influence of asbestos is lacking. The nationwide regional incidence
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-13 (2021)
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology, 2021, 22 (1), pp.51. ⟨10.1186/s12860-021-00388-0⟩
BMC Molecular and Cell Biology, BioMed Central, 2021, 22 (1), ⟨10.1186/s12860-021-00388-0⟩
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology, 2021, 22 (1), pp.51. ⟨10.1186/s12860-021-00388-0⟩
BMC Molecular and Cell Biology, BioMed Central, 2021, 22 (1), ⟨10.1186/s12860-021-00388-0⟩
Background Apoptosis is a caspase regulated cell death present in all metazoans defined by a conserved set of morphological features. A well-described function of apoptosis is the removal of excessive cells during development and homeostasis. Recent