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Autor:
Luciane Aparecida Pascucci Sande de Souza, Gustavo José Luvizutto, Pablo Andrei Appelt, Kristin Comella
Publikováno v:
Cerebellum & Ataxias, Vol 8, Iss 1, Pp 1-9 (2021)
Cerebellum & Ataxias
Cerebellum & Ataxias
Background Spinocerebellar ataxia is a hereditary neurodegenerative disease characterized by changes in balance, locomotion and motor coordination. Stem cell therapies are currently being investigated as an alternative to delay the evolution of the d
Autor:
Yu Dong, Hua-Bing Li, Duan Ni, Rujuan Bao, Yanhua Du, Xiaoyin Niu, Zhenzhen Xun, Huifang Chen, Youqiong Ye, Jiameng Yao, Gaoyang Wang, Ting Zhang
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-21 (2021)
Molecular Cancer
Molecular Cancer
BackgroundThe four major RNA adenosine modifications, i.e., m6A, m1A, alternative polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” enzymes and constitute critical mechanisms of epigenetic regulation in im
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Cancer
BMC Cancer
Background The aim of this study was to assess the survival outcomes of cisplatin-paclitaxel chemotherapy plus bevacizumab (CPB) versus cisplatin-paclitaxel chemotherapy alone (CPA) in postmenopausal women with previously untreated advanced cervical
Publikováno v:
Journal of Ovarian Research, Vol 14, Iss 1, Pp 1-16 (2021)
Journal of Ovarian Research
Journal of Ovarian Research
Improving early diagnosis along with timely and effective treatment of COVID-19 are urgently needed. However, at present, the mechanisms underlying disease spread and development, defined prognosis, and immune status of patients with COVID-19 remain
Autor:
Gabriela Fragoso, Manuela M. Santos, Roy Hajjar, Thibault Cuisiniere, Manon Oliero, Annie Calvé, Ulrich Dobrindt
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
BMC Cancer
BMC Cancer
Background Colibactin is a genotoxin that induces DNA double-strand breaks that may lead to carcinogenesis and is produced by Escherichia coli strains harboring the pks island. Human and animal studies have shown that colibactin-producing gut bacteri
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-12 (2021)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
BRAF and KRAS are two key oncogenes in the RAS/RAF/MEK/MAPK signaling pathway. Concomitant mutations in both KRAS and BRAF genes have been identified in non-small cell lung cancer (NSCLC). They lead to the proliferation, differentiation, and apoptosi
Autor:
Jihui Wang, Jie Liu, Huajian Chen, Shaokang Deng, Yang Liu, Taoliang Chen, Yiquan Ke, Xiangdong Xu, Min Huang, Yaofeng Zheng, Xinlin Sun, Yuxuan Zhang, Yan Li
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-20 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Exosomes are membrane-bound extracellular vesicles of 40–150 nm in size, that are produced by many cell types, and play an important role in the maintenance of cellular homeostasis. Exosome secretion allows for the selective removal of h
Publikováno v:
Cancer Imaging, Vol 21, Iss 1, Pp 1-9 (2021)
Cancer Imaging
Cancer Imaging
Anti-programmed cell death-1 (PD-1)/programmed death ligand-1 (PD-L1) antibodies are administered in varied human cancer types. The expression of PD-L1 within tumor cells has been identified as a predictive marker, although assessing its expression h
Autor:
Fang Hu, Xue-Ping Li, Jianming Zhang, Si-Yuan He, Dawei Wang, Wei-Na Zhang, Yu-Jun Dai, Si-Liang Chen, Hai-Min Sun
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-7 (2021)
Molecular Cancer
Molecular Cancer
Acute myeloid leukemia (AML) is still incurable due to its heterogeneity and complexity of tumor microenvironment. It is imperative therefore to understand the molecular pathogenesis of AML and identify leukemia-associated biomarkers to formulate eff
Autor:
Martha M. Grimes, Yuna Guo, Dayna Dominguez, Laurie G. Hudson, Angela Wandinger-Ness, Kathryn J. Brayer, S. Ray Kenney
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-16 (2021)
BMC Cancer
BMC Cancer
Background Rho-family GTPases, including Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division control protein 42 (Cdc42), are important modulators of cancer-relevant cell functions and are viewed as promising therapeutic targets. Based