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Publikováno v:
Cancer Medicine
Patients with nonresectable metastatic neuroendocrine tumors (NETs) experience symptoms of hormone hypersecretion including diarrhea, flushing, and bronchoconstriction, which can interfere with quality of life [Anthony and Vinik (2011) Pancreas, 40:9
Autor:
Maria Tscherner, Diana Zabini, Walter Klepetko, Grazyna Kwapiszewska, Leigh M. Marsh, Slaven Crnkovic, Bahil Ghanim, Hui Xu, Andrea Olschewski
Publikováno v:
Journal of Cellular and Molecular Medicine
Extracellular high-mobility group box-1 (HMGB1) acts as a signalling molecule during inflammation, cell differentiation and angiogenesis. Increased abundance of HMGB1 is associated with several pathological disorders such as cancer, asthma and chroni
Autor:
Chihaya Hinohara, Teruki Hagiwara, Yuki I. Kawamura, Oki Miyake, Toshio Shimizu, Miwa Tamura-Nakano, Takuhito Sezaki, Takeshi Otsubo, Taeko Dohi, Kazuhiko Yamada
Publikováno v:
Cancer Medicine
Periplakin (PPL), a member of the plakin family of proteins that localizes to desmosomes and intermediate filaments, is downregulated in human esophageal squamous cell carcinoma (ESCC). Little is known, however, about the molecular mechanism underlyi
Autor:
Mari Nishio, Nobuhisa Takase, Soken Utsunomiya, Hiroshi Yokozaki, Naoki Urakawa, Takahide Komori, Yu-ichiro Koma, Yoshihiro Kakeji, Hiroaki Akiyama, Manabu Shigeoka
Publikováno v:
Cancer Medicine
Tumor-associated macrophages (TAMs) are known to be involved in the progression of various human malignancies. We previously demonstrated that CD204 was a useful marker for TAMs contributing to the angiogenesis, progression, and prognosis of human es
Autor:
Dennis C. Shrieve, Kenneth M. Boucher, Li Ming Christine Fang, Leechuan Andy Chen, Luke O. Buchmann, Ying J. Hitchcock, Kenneth F. Grossmann, Jason P. Hunt, Christopher J. Anker
Publikováno v:
Cancer Medicine
Curative treatment for base-of-tongue squamous cell carcinoma (BOT SCC) has evolved over time; however, comparative outcomes analysis for various treatment strategies is lacking. The authors reviewed the evolution of treatment modality and radiothera
Autor:
Joyce Steinberg, Rene Gonzalez, Fei Jie, Bruce G. Redman, Ragini R. Kudchadkar, Bartosz Chmielowski, Caroline Chen, Anne Keating, Jeffrey S. Weber, Scott Ernst
Publikováno v:
Cancer Medicine
Survivin is a microtubule-associated protein believed to be involved in preserving cell viability and regulating tumor cell mitosis, and it is overexpressed in many primary tumor types, including melanoma. YM155 is a first-in-class survivin suppressa
Autor:
Mary E. Griffith, Lauren M. Rosati, Joseph M. Herman, Eileen M. O'Reilly, Amy Hacker-Prietz, Timothy M. Pawlik, Siva P. Raman, Elizabeth A. Sugar, Lei Zheng, Jonathan S. Pai, Aaron T. Wild, George A. Fisher, Christopher L. Wolfgang, Daniel A. Laheru, Laurie Ann Columbo, Avani S. Dholakia, Daniel T. Chang, Karyn A. Goodman, Albert C. Koong, Christine A. Iacobuzio-Donahue
Publikováno v:
Cancer
Background This phase 2 multi-institutional study was designed to determine whether gemcitabine (GEM) with fractionated stereotactic body radiotherapy (SBRT) results in acceptable late grade 2 to 4 gastrointestinal toxicity when compared with a prior
Autor:
Victoria L. Bae-Jump, Megan Difurio, Paola A. Gehrig, K.M. Schuler, Liza Makowski, Brante P. Sampey, Brooke S. Rambally
Publikováno v:
Cancer Medicine
We conducted a preoperative window study of metformin in endometrial cancer (EC) patients and evaluated its antiproliferative, molecular and metabolic effects. Twenty obese women with endometrioid EC were treated with metformin (850 mg) daily for up
Publikováno v:
Cancer Science
Vascular endothelial growth factor (VEGF)-C is an important lymphangiogenic factor involved in the lymphangiogenesis of gallbladder carcinoma (GBC) and the lymph node metastasis of the tumor. Tumor necrosis factor (TNF)-α, a key inflammatory cytokin
Publikováno v:
Cancer Science
Somatic mutations in splicing factor genes have frequently been reported in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Although aberrant epigenetic changes are frequently implicated in blood cancers, their direct role in suppre