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Autor:
Fumi Fuchinoue, Shinobu Masuda, Tetsuyo Maeda, Yukari Obana, Misato Iizuka, Mayumi Tani, Katsuhisa Enomoto, Sadao Amano, Eriko Murakami, Yoko Nakanishi, Kenichi Sakurai
Publikováno v:
Cancer Science
MUC1 glycoprotein is overexpressed and its intracellular localization altered during breast carcinoma tumorigenesis. The present study aimed to clarify the relationship of cytoplasmic localization of MUC1 with the breast cancer subtype and the correl
Autor:
Kaoru Niimi, Naoki Watanabe, Eiko Yamamoto, Masato Asai, Atsushi Enomoto, Masahide Takahashi, Yoshiki Murakumo, Kiyosumi Shibata, Shinji Mii, Hiroaki Kajiyama, Takuya Kato, Naoya Asai, Fumitaka Kikkawa
Publikováno v:
Cancer Science
Human REV7 (also known as MAD2L2 and MAD2B) is involved in DNA repair, cell cycle regulation, gene transcription, and carcinogenesis. In this study, we evaluated the expression of REV7 in epithelial ovarian cancer (EOC) and analyzed the association b
Autor:
Yoshifumi Yamamoto, Toshimichi Yasui, Yukinori Takenaka, Hiromi Maruyama, Tadashi Yoshii, Hidenori Inohara, Susumu Nakahara, Eiichi Morii, Tomoko Ishikawa-Fujiwara, Takeshi Todo, Tadashi Hongyo
Publikováno v:
Cancer Science
We aimed to reveal the prevalence and pattern of human papillomavirus (HPV) infection and p53 mutations among Japanese head and neck squamous cell carcinoma (HNSCC) patients in relation to clinicopathological parameters. Human papillomavirus DNA and
Publikováno v:
Cancer Medicine
Somatic mutations in cancer cell genes are classified according to their functional significance. Those that provide the malignant cells with significant advantage are collectively referred to as driver mutations and those that do not, are the passen
Autor:
Kelvin Chingchung Tseng, Chin-Hsiao Tseng, Ann-Joy Cheng, Hung-Ming Wang, Joseph Tung-Chieh Chang, I-How Chen, Ching Ping Tseng, Chun-Ta Liao
Publikováno v:
Japanese Journal of Cancer Research : Gann
Progression of head and neck cancer is always associated with changes of gene expression profile. In this study, we characterized the expression of multidrug‐resistance mdr1 gene, which may play a role in tumorigenesis and multidrug resistance in h
Autor:
Norihisa Shingu, Katsuyuki Aozasa, Shin-ichi Nakatsuka, Taisei Nomura, Tadashi Hongyo, Mukh Syaifudin
Publikováno v:
Japanese Journal of Cancer Research : Gann
Malignant lymphoma of the adrenal gland is a rare disease, usually with diffuse large cell morphology and B-cell immunophenotype, and often associated with Epstein-Barr virus infection. In this study, mutations of p53, c-kit, K-ras, and beta-catenin
Autor:
Mitsugu Hironaka, Sachiko Oguni, Masashi Fukayama, Shinji Sakurai, Shojiroh Morinaga, Ken Saito
Publikováno v:
Japanese Journal of Cancer Research : Gann
Gain-of-function mutation in c-kit proto-oncogene exon 11 has been described in about 20 -- 50% of gastrointestinal stroma tumor (GIST). Recently, additional mutational hot-spots in exon 9 and exon 13 of the c-kit gene have been reported in GISTs wit
Autor:
Chyi-Chia Richard Lee, Seiji Wada, Mitsuhiro Tada, Keisuke Yamamoto, Taketoshi Kishimoto, Shoji Fukushima, Shinji Yamamoto, Chikayoshi Masuda, Hideki Wanibuchi, Rikio Yoshimura
Publikováno v:
Japanese Journal of Cancer Research : Gann
Scopus-Elsevier
Scopus-Elsevier
Multifocal synchronous or metachronous tumor development is a common observation in human urothelial cancer cases. However, the underlying mechanism has remained obscure. We have employed a new tool to investigate the p53 gene status, the yeast p53 f
Publikováno v:
Japanese Journal of Cancer Research : Gann
We have investigated 114 cases with diffuse large B-cell lymphoma (DLBCL) to clarify the characteristics of DLBCL with Epstein-Barr virus (EBV) infection. Thirteen cases (11.4%) showed EBV-encoded RNA 1 (EBER1) signals by RNA in situ hybridization. E
Autor:
Naoki Yoshimi, Takashi Yoshioka, Masashi Kimura, Masahiro Katada, Manabu Futamura, Shigetoyo Saji, Takao Takahashi, Yukihiro Takagi, Jun Sano, Yukio Okano
Publikováno v:
Japanese Journal of Cancer Research : Gann
Members of the recently identified family of Homo sapiens Aurora / Ipl1-related kinases (HsAIRKs), homologous to chromosome segregation kinases, fly Aurora and yeast Ipl1, are highly expressed during M phase, and have been suggested to regulate centr