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Publikováno v:
Cancer Medicine
Somatic mutations in cancer cell genes are classified according to their functional significance. Those that provide the malignant cells with significant advantage are collectively referred to as driver mutations and those that do not, are the passen
Autor:
Zhi-Nan Chen, Sihe Zhang, Zheng Zhang, Liang Chen, Jinliang Xing, Ling-Min Kong, Hushan Yang, Cheng-Gong Liao, Huijie Bian
Publikováno v:
Journal of Cellular and Molecular Medicine
CD147 is a transmembrane glycoprotein overexpressed in human hepatocellular carcinoma (HCC) which could promote HCC progression and metastasis. Promoter methylation is one of the most important processes in gene regulation. In this study, we aim to i
Publikováno v:
Japanese Journal of Cancer Research : Gann
We have investigated 114 cases with diffuse large B-cell lymphoma (DLBCL) to clarify the characteristics of DLBCL with Epstein-Barr virus (EBV) infection. Thirteen cases (11.4%) showed EBV-encoded RNA 1 (EBER1) signals by RNA in situ hybridization. E
Publikováno v:
Japanese Journal of Cancer Research : Gann
In individuals who carry germline mutations in tumor suppressor genes predisposing them to inherited cancer syndromes, occurrence of somatic mutations in the same genes contributes to tumorigenesis. Germline mutations in the RET proto-oncogene predis
Publikováno v:
Japanese Journal of Cancer Research : Gann
Invasive proliferation is a critical biological characteristic of gliomas. We evaluated the activities of hepatocyte growth factor (HGF) on proliferation and motility of glioma cells, comparing them with the effects of other growth factors (EGF, bFGF
Publikováno v:
Japanese Journal of Cancer Research : Gann
Genomic DNA was extracted from aspiration biopsy specimens taken from 15 suspected cases of breast cancer, including 7 known cases of breast cancer, and the p53 gene was studied for evidence of mutation by using a polymerase chain reaction-single str
Autor:
Kiyoshi Takatsuki, Masanori Hayami, Sigeo Mori, Toshiki Watanabe, Manabu Mochizuki, S Araki, Kazunari Yamaguchi, Ayako Ono, Tomoyuki Miura
Publikováno v:
Japanese Journal of Cancer Research : Gann
The hypothesis that HTLV-1 uveitis, a recently identified disease entity associated with human T-cell leukemia virus type I (HTLV-1), is caused by a specific subtype of the virus was tested. The nucleotide sequences of the long terminal repeat of HTL
Autor:
Toshikazu Ushijima, Jun Shimazaki, Ryuichi Yatani, Minako Nagao, Masatoshi Watanabe, Takashi Sugimura, Hideki Kakiuchi, Toshihiko Kotake, Taizo Shiraishi
Publikováno v:
Japanese Journal of Cancer Research : Gann
Scopus-Elsevier
Scopus-Elsevier
The involvement of p53 mutations in prostate cancers in Japan was investigated. To evaluate any possible clinicopathological significance, p53 mutations in 40 samples from 36 Japanese prostate cancers of different stages (five cases of latent tumors,
Autor:
Osamu Yamakawa, Takashi Okai, Hirokazu Takahashi, Hiroyuki Watanabe, Norio Sawabu, Tokio Wakabayashi, Yoshiharu Motoo, Yoshitake Satomura, Hideki Ohta
Publikováno v:
Japanese Journal of Cancer Research : Gann
Pancreatic cancer is detected on the basis of morphological changes delineated by means of various image-diagnostic methods. However, differentiation between chronic pancreatitis and pancreatic cancer, especially at the early stage, is not always sim
Publikováno v:
Japanese Journal of Cancer Research : Gann
Types and certain genetic markers were studied for Epstein-Barr virus present in 10 specimens of nasopharyngeal carcinoma (NPC) from Japanese patients. The type 1 virus was predominant in our NPC specimens, as in the general Japanese population, and