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Publikováno v:
Endocr Relat Cancer
Immune checkpoint inhibitors have shown promising results in different cancers, and correlation between immune infiltration, expression of programmed death-ligand 1 (PD-L1) by tumor cells and response to immunotherapy has been reported. There is limi
Autor:
Alfredo Berruti, Paola Sperone, Giorgio V. Scagliotti, Ester Oneda, Ida Rapa, Mauro Papotti, Martin Fassnacht, Massimo Terzolo, Laura Ferrari, Marco Volante, Salvatore Grisanti, Antonina Germano, Elisa Roca, Cristina L Ronchi, Silviu Sbiera, Barbara Zaggia
Publikováno v:
Endocrine-Related Cancer. :319-327
Topoisomerase II alpha (TOP2A) and thymidylate synthase (TS) are known prognostic parameters in several tumors and also predictors of efficacy of anthracyclines, topoisomerase inhibitors and fluoropirimidines, respectively. Expression ofTOP2AandTSmRN
Autor:
Daniel Cuevas-Ramos, Takako Araki, Yukiko Tone, Ning-Ai Liu, Shlomo Melmed, Roy Heltsley, Masahide Tone
Publikováno v:
Endocrine-Related Cancer. 23:857-870
Cushing’s syndrome is caused by excessive adrenocorticotropic hormone (ACTH) secretion derived from pituitary corticotroph tumors (Cushing disease) or from non-pituitary tumors (ectopic Cushing’s syndrome). Hypercortisolemic features of ectopic C
Autor:
Hong Xie, Martin Bäckdahl, Linkiat Lee, Deniz M. Ozata, Weng-Onn Lui, Jan Zedenius, Catharina Larsson, Pinar Akcakaya, Anders Höög, Stefano Caramuta
Publikováno v:
Endocrine-Related Cancer
Deregulation of microRNA (miRNA) expression in adrenocortical carcinomas (ACCs) has been documented to have diagnostic, prognostic, as well as functional implications. Here, we evaluated the mRNA expression ofDROSHA,DGCR8,DICER(DICER1),TARBP2, andPRK
Autor:
Marianne Pavel, Katharina Detjen, Henning Jann, Tabea Neumann, Georg Hilfenhaus, Andreas Göhrig, Ulrich-Frank Pape, Dietmar Zdunek, Jean Marie Stassen, Georg Hess, Christian Fischer, Bertram Wiedenmann
Publikováno v:
Endocrine-Related Cancer. 20:305-319
Placental growth factor (PlGF), a VEGF-homolog implicated in tumor angiogenesis and adaptation to antiangiogenic therapy, is emerging as candidate target in malignancies. Here, we addressed the expression, function, and prognostic value of PlGF in ne
Autor:
Xihong Lin, Jennifer A. Chan, Laurie Buchanan, Rachel Heafield, Monica Ter-Minassian, David C. Christiani, Matthew H. Kulke, Charles S. Fuchs, Anastassia Daskalova, ZhiRong R Qian, Susanne M. Hooshmand, Lauren K. Brais
Publikováno v:
Endocrine-Related Cancer. 20:187-196
The rarity of neuroendocrine tumors (NET) has contributed to a paucity of large epidemiologic studies of patients with this condition. We characterized presenting symptoms and clinical outcomes in a prospective database of over 900 patients with NET.
Autor:
Michael Hoffmeister, Asta Försti, Bernd Frank, Kari Hemminki, Anja Rudolph, Jenny Chang-Claude, Hermann Brenner, Rebecca Hein, Juan Sainz
Publikováno v:
Endocrine Related Cancer. 18:371-384
The mechanisms underlying the association of menopausal hormone therapy (MHT) with reduced colorectal cancer (CRC) risk are unknown and the identification of genetic modifiers may yield further insight. We explored the effect modification of MHT-asso
Autor:
Patricia de Cremoux, Daniel W. Rosenberg, Jérôme Bertherat, Lionnel Groussin, Catherine Brémont-Weil, Marie-Laure Raffin-Sanson, Carine Tran-Perennou, Xavier Bertagna, Frédérique Tissier, Jacques Goussard
Publikováno v:
Endocrine Related Cancer. 15:465-474
Adrenal tumors occur more frequently in women and are the leading cause of Cushing's syndrome during pregnancy. We aimed to evaluate the potential role of sex steroids in the susceptibility of women to adrenocortical tumors. We evaluated the presence
Autor:
Chiara Cappelletti, Marco F. Manzoni, Cecilia Piani, Paolo Giorgio Arcidiacono, Emanuele Bosi, Luca Albarello, Alessandro Zerbi, Giulia M. Franchi, Marina Scavini
Publikováno v:
Endocrine Related Cancer. 15:175-181
The cytological Ki-67 expression measured on cytological samples collected by endoscopic ultrasonography-guided fine needle aspiration cytology (EUS-FNAC) may provide pre-operative indications for pancreatic endocrine tumours (PETs) management. The a
Autor:
Takuya Moriya, Takanori Ishida, Katsuhiko Ono, Jun Ichi Akahira, Dean B. Evans, Kimako Yoshida, Takashi Suzuki, Hironobu Sasano, Yasuhiro Miki, Hisashi Hirakawa, Rie Shibuya
Publikováno v:
Endocrine Related Cancer. 15:113-124
It is well known that sex steroids play important roles in the development of invasive ductal carcinoma (IDC) of the human breast. However, biological significance of sex steroids remains largely unclear in ductal carcinoma in situ (DCIS), regarded a