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Background Access to protocols and statistical analysis plans (SAPs) increases the transparency of randomised trial by allowing readers to identify and interpret unplanned changes to study methods, however they are often not made publicly available.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6002cc3ed55a6949ca38f914702ad6
http://hdl.handle.net/10044/1/103334
http://hdl.handle.net/10044/1/103334
Autor:
Monica Arribas, Vipul Jairath, Katharine Ker, Amy Brenner, Haleema Shakur-Still, Jack Cuzick, Ian Roberts, Simon J. Stanworth
Publikováno v:
Trials
Trials, Vol 19, Iss 1, Pp 1-7 (2018)
Trials, Vol 19, Iss 1, Pp 1-7 (2018)
Background Acute severe haemorrhage is a common complication of injury, childbirth, surgery, gastrointestinal pathologies and other medical conditions. Bleeding is a major cause of death, but patients also die from non-bleeding causes, the frequency
Autor:
Vipul Jairath, Brennan C Kahan
Publikováno v:
Trials
Trials, Vol 19, Iss 1, Pp 1-5 (2018)
Trials, Vol 19, Iss 1, Pp 1-5 (2018)
Background Pre-specification of outcomes is an important tool to guard against outcome switching in clinical trials. However, if the outcome is not sufficiently clearly defined, then different definitions could be applied and analysed, with only the
Autor:
Neil Wright, Richard Hooper, Sandra Eldridge, Yunus Ali, Clemence Leyrat, Brennan C Kahan, Vipul Jairath, Gordon Forbes, Stephen Bremner, Michael O. Harhay
Publikováno v:
Trials
Background: Cluster randomised trials (CRTs) are commonly analysed using mixed-effects models or generalised estimating equations (GEEs). However, these analyses do not always perform well with the small number of clusters typical of most CRTs. They
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce46a4a52b2776b8b6bd21dbf20ed73
Autor:
Vipul Jairath, Brennan C Kahan
Publikováno v:
Trials
Blinded outcome assessment is a key component of randomised trials, as unblinded assessment can lead to bias. However, in some circumstances blinded assessment may be difficult to achieve. In these situations, it may be useful to modify the outcome d