Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gary J. Nabel"'
Autor:
Kaifan Dai, Zhi-Yong Yang, Gary J. Nabel, D Lingwood, Peter D. Kwong, John R. Mascola, Stephen D. Schmidt, Wei Shi, Ivelin S. Georgiev, J.C. Boyington
Publikováno v:
Retrovirology
Retrovirology, Vol 9, Iss Suppl 2, p P23 (2012)
Retrovirology, Vol 9, Iss Suppl 2, p P23 (2012)
Methods In this study, we used structural information of HIV gp120 core, together with the computer-assisted protein design tool to strategically add various glycosylation sites on the protein surface and create a panel of resurfaced stabilized core
Publikováno v:
Retrovirology
Retrovirology, Vol 9, Iss Suppl 2, p P318 (2012)
Retrovirology, Vol 9, Iss Suppl 2, p P318 (2012)
Background HIV-1 gp120 monomer-based probes have been used for the identification of broadly neutralizing antibodies. Such probes could represent starting points in the design of HIV-1 immunogens, though efforts must be made to silence immune respons
Autor:
Gary J. Nabel, Stephen C. DeRosa, Barney S. Graham, Edith Swann, Nidhi Kochar, Cecilia Morgan, Pierre-Alexandre Bart, Hua-Xin Liao, Peter B. Gilbert, Nicole Frahm, Barton F. Haynes, Georgia D. Tomaras, Jonathan D. Fuchs
Publikováno v:
Retrovirology
Retrovirology, Vol 9, Iss Suppl 2, p P136 (2012)
Retrovirology, Vol 9, Iss Suppl 2, p P136 (2012)
High frequency responses were elicited against clade A (T1 95.8%, T2 100%, T3 97.4%, T4 100%), clade B (T1 95.8%, T2 95.0%, T3 92.1%, T4 96.3%), clade C (T1 92%, T2 76%, T3 76%, T4 78%), and Con S (T1-4 100%). There were no significant between-group
Publikováno v:
Retrovirology
Background The HIV cellular receptor, CD4, is not subject to the high rate of mutation found in viral gene products. Therefore antibodies that target the gp120 binding domain of CD4 that do not interfere with its physiological role might provide an e
Autor:
Mitsuo Honda, Daniel D. Pinschewer, Rahul Roychoudhuri, Z Yang, Sung-Youl Ko, Ling Xu, Lukas Flatz, Wing-Pui Kong, Lingshu Wang, Gary J. Nabel
Publikováno v:
Retrovirology
Europe PubMed Central
Retrovirology, Vol 6, Iss Suppl 3, p P357 (2009)
Europe PubMed Central
Retrovirology, Vol 6, Iss Suppl 3, p P357 (2009)
Background Immunization against chronic life threatening viral infections such as HIV remains an elusive goal. Data from clinical and non-human primate studies suggest that the generation of potent CD8 T cell responses as well as broadly neutralizing