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Publikováno v:
BMC Anesthesiology
Background Activation of NMDA receptors play an important role in the development of remifentanil-induced hyperalgesia. We hypothesized that in addition to ketamine, intrathecal MgSO4 could also relieve thermal and mechanical hyperalgesia in rats. Me
Anti-nerve growth factor antibody attenuates chronic morphine treatment-induced tolerance in the rat
Publikováno v:
BMC Anesthesiology
Background Nerve growth factor (NGF) is known to induce inflammation and pain; however its role in opioid-induced tolerance has not been studied. This study investigated the effects of an anti-NGF neutralizing antibody on the development of tolerance
Publikováno v:
BMC Anesthesiology
Background Morphine-induced hyperalgesia and tolerance significantly limits its clinical use in relieving acute and chronic pain. Melatonin, a pineal gland neurohormone, has been shown to participate in certain neuropsychopharmacological actions. The
Publikováno v:
Molecular Pain
Background: Gabapentin (GBP) is known to suppress neuropathic hypersensitivity of primary afferents and the spinal cord dorsal horn. However, its supra-spinal action sites are unclear. We identify the brain regions where GBP changes the brain glucose
Autor:
Ganesh A. Thakur, Kiran Vemuri, Yvonne Lai, Elizabeth J. Rahn, Alexander M. Zvonok, Liting Deng, Alexandros Makriyannis, Andrea G. Hohmann
Publikováno v:
Molecular Pain
Background Chemotherapeutic treatment results in chronic pain in an estimated 30-40 percent of patients. Limited and often ineffective treatments make the need for new therapeutics an urgent one. We compared the effects of prophylactic cannabinoids a
Autor:
Wen Wang, Ming Zhu Zhai, Xiao Peng Mei, Hui Zhang, Wei Wang, Yun-Qing Li, Yan Yan Wei, Li Xian Xu
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 8, Iss 1, p 6 (2011)
Journal of Neuroinflammation, Vol 8, Iss 1, p 6 (2011)
Background We have previously reported that inhibition of astrocytic activation contributes to the analgesic effects of intrathecal ketamine on spinal nerve ligation (SNL)-induced neuropathic pain. However, the underlying mechanisms are still unclear
Autor:
Juan Herrero, M. Mar Curros-Criado
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 4, Iss 1, p 15 (2007)
Journal of Neuroinflammation, Vol 4, Iss 1, p 15 (2007)
Background Gabapentin is a structural analogue of gamma-aminobutyric acid with strong anticonvulsant and analgesic activities. Important discrepancies are observed on the effectiveness and potency of gabapentin in acute nociception and sensitization