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Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-25 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-25 (2021)
CRISPR (clustered regularly interspaced short palindromic repeats) systems are one of the most fascinating tools of the current era in molecular biotechnology. With the ease that they provide in genome editing, CRISPR systems generate broad opportuni
Autor:
Mateusz Adam Krzyścik, Marta Poźniak, Agnieszka Barbach, Marika Kucińska, Malgorzata Zakrzewska, Kamil Jastrzębski, Weronika Zarzycka, Marta Miączyńska, Natalia Porębska, Jacek Otlewski, Łukasz Opaliński
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-21 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-21 (2021)
Background Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer treatment with cytotoxic conjugates. The success of cancer therapy with cytotoxic conjugates
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-14 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-14 (2021)
Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a pivotal ro
Autor:
Chien-Huang Lin, Hung Sheng Hua, Hong Sheng Lee, Bing Chang Chen, Chih Ming Weng, Heng Ching Wen
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-12 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-12 (2021)
Background Histone deacetylase (HDAC) inhibition was reported to ameliorate lung fibrosis in animal models. However, little is known about the underlying mechanism of HDAC7 in the regulation of CTGF production in lung fibroblasts. Methods The role of
Autor:
Natthaphat Siri-Angkul, Chanon Piamsiri, Chayodom Maneechote, Nipon Chattipakorn, Siriporn C. Chattipakorn
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-13 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-13 (2021)
Cardiovascular diseases (CVDs) are considered the predominant cause of morbidity and mortality globally. Of these, myocardial infarction (MI) is the most common cause of CVD mortality. MI is a life-threatening condition which occurs when coronary per
Autor:
Sara Socorro Faria, Mickaël Rialland, Victor Pianna de Andrade, Susan Costantini, Alfredo Budillon, Vladmir Cláudio Cordeiro de Lima, Kelly Grace Magalhães, Rebe Cedric
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-15 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-15 (2021)
Breast cancer is the most diagnosed malignancy in women. Increasing evidence has highlighted the importance of chronic inflammation at the local and/or systemic level in breast cancer pathobiology, influencing its progression, metastatic potential an
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-16 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-16 (2021)
Although rheumatoid arthritis affects 1% of the global population, the role of rheumatoid cachexia, which occurs in up to a third of patients, is relatively neglected as research focus, despite its significant contribution to decreased quality of lif
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-10 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-10 (2021)
Glioblastoma is the most common primary malignant brain tumor that is usually considered fatal even with treatment. This is often a result for tumor to develop resistance. Regarding the standard chemotherapy, the alkylating agent temozolomide is effe
Autor:
Evangelos Terpos, Meletios-Athanasios Dimopoulos, Ourania E. Tsitsilonis, George N. Pavlakis, Ioannis P. Trougakos, Efstathios Kastritis, Kimon Stamatelopoulos, Dimitrios Paraskevis, Evmorfia Aivalioti
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-18 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-18 (2021)
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse effects (e.g., multi-organ col
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-18 (2021)
Journal of Biomedical Science
Journal of Biomedical Science
Background NKX3.1, a prostate-specific tumor suppressor, is either genomically lost or its protein levels are severely downregulated, which are invariably associated with poor prognosis in prostate cancer (PCa). Nevertheless, a clear disconnect exist
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https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ebb931f24791d0690ab71588e02b29