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Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-25 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-25 (2021)
CRISPR (clustered regularly interspaced short palindromic repeats) systems are one of the most fascinating tools of the current era in molecular biotechnology. With the ease that they provide in genome editing, CRISPR systems generate broad opportuni
Publikováno v:
Journal of Cardiothoracic Surgery
Journal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-7 (2021)
Journal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-7 (2021)
Background SCIRT has been characterized as a key player in cancer biology, while its role in other human diseases is unclear. This study explored its role in atherosclerosis, with a specific focus on its interaction with SCIRT and miR-146a. Methods T
Autor:
Francesco M. Marincola, Lingyu Li, Rona Harari-Steinfeld, Bing Wang, Lei S. Qi, Veena Vinod, Kyung-Ho Roh, Bennett Alphson, Damla Inel, Jin Yang, Alper Kearney, Zhifen Yang, Maggie Bobbin, Ofir Stefanson, Ahu Turkoz, Pohan Chen, Violena Pietrobon, Alessandra Cesano, Vitaly Balan, Dharmesh Patel, Hana Choi, Angshumala Goswami
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-18 (2021)
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-18 (2021)
Background Adoptive transfer of chimeric antigen receptor (CAR)-engineered T cells combined with checkpoint inhibition may prevent T cell exhaustion and improve clinical outcomes. However, the approach is limited by cumulative costs and toxicities. M
Autor:
Mateusz Adam Krzyścik, Marta Poźniak, Agnieszka Barbach, Marika Kucińska, Malgorzata Zakrzewska, Kamil Jastrzębski, Weronika Zarzycka, Marta Miączyńska, Natalia Porębska, Jacek Otlewski, Łukasz Opaliński
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-21 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-21 (2021)
Background Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer treatment with cytotoxic conjugates. The success of cancer therapy with cytotoxic conjugates
Publikováno v:
European Journal of Medical Research
European Journal of Medical Research, Vol 26, Iss 1, Pp 1-10 (2021)
European Journal of Medical Research, Vol 26, Iss 1, Pp 1-10 (2021)
Background Platelet-rich plasma (PRP) has the potential to be used for bone regeneration. However, its effect on osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and its effect on cell autophagy of hPDLSCs remain unknown.
Autor:
Xiaoe Zhang, Dejun Sun, Yumin Gao, Juan Sun, Xulong Zhang, Yuan Xia, Qingjun Cai, Qihao Wang, Li Wang
Publikováno v:
Particle and Fibre Toxicology
Particle and Fibre Toxicology, Vol 18, Iss 1, Pp 1-23 (2021)
Particle and Fibre Toxicology, Vol 18, Iss 1, Pp 1-23 (2021)
BackgroundThis study aims to investigate the effects of water soluble particulate matter (WSPM) on the viability and protein expression profile of human lung adenocarcinoma cell A549 in the Bayou Obo rare earth mining area, and explore the influence
Autor:
Per Arne Aas, Renana Rabe, Vuk Palibrk, Geir Slupphaug, Kristian Lied Wollen, Lars Hagen, Davi de Miranda Fonseca, Hilde O. Erlandsen, Animesh Sharma, Cathrine Broberg Vågbø, Tobias S. Iveland, Magnar Bjørås, Bjørnar Sporsheim, Nima Mosammaparast
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-22 (2021)
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-22 (2021)
Background Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifications and whether cells distinguish aberrant from
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-14 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-14 (2021)
Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a pivotal ro
Autor:
Chien-Huang Lin, Hung Sheng Hua, Hong Sheng Lee, Bing Chang Chen, Chih Ming Weng, Heng Ching Wen
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-12 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-12 (2021)
Background Histone deacetylase (HDAC) inhibition was reported to ameliorate lung fibrosis in animal models. However, little is known about the underlying mechanism of HDAC7 in the regulation of CTGF production in lung fibroblasts. Methods The role of
Autor:
Natthaphat Siri-Angkul, Chanon Piamsiri, Chayodom Maneechote, Nipon Chattipakorn, Siriporn C. Chattipakorn
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-13 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-13 (2021)
Cardiovascular diseases (CVDs) are considered the predominant cause of morbidity and mortality globally. Of these, myocardial infarction (MI) is the most common cause of CVD mortality. MI is a life-threatening condition which occurs when coronary per