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Publikováno v:
BMC Cancer
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Background Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in head and neck. Platinum-based chemotherapy is an important treatment for NPC. However, the molecular mechanism of resistance to platinum drug remains unknown. Endopla
Autor:
Jana Plava, Lucia Rojikova, Bozena Smolkova, Lenka Trnkova, Monika Burikova, Pavel Babal, Lubos Danisovic, Svetlana Miklikova, Lucia Kucerova, Pavol Janega, Lucia Krivosikova, Marina Cihova, Martin Bohac, Slávka Drahošová
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-15 (2021)
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-15 (2021)
Background Chemotherapy remains a standard treatment option for breast cancer despite its toxic effects to normal tissues. However, the long-lasting effects of chemotherapy on non-malignant cells may influence tumor cell behavior and response to trea
Autor:
Olga Gielen, Inge Govaerts, Jan Cools, Kris Jacobs, Nancy Boeckx, Sarah Provost, David Nittner, Kim De Keersmaecker, Cristina Prieto, Johan Maertens, Heidi Segers, Charlien Vandersmissen
Publikováno v:
Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-14 (2021)
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-14 (2021)
Background T cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype that comprises 10–15% of childhood and 20–25% of adult ALL cases. Over 70% of T-ALL patients harbor activating mutations in the NOTCH1 signaling pathway and are predict
Autor:
Wenjin Yin, Jinsong Lu, Yueyao Du, Rui Sha, Jing Peng, Liheng Zhou, Fan Yang, Shuguang Xu, Yifan Wu, Huijuan Dai, Xiaonan Sheng, Yanping Lin
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)
Background Triple negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and lack of effective treatment target. Here we screened differentially expressed lncRNAs through bioinformatics analysis and identified CARMN as a down
Autor:
Yasutoshi Yamada, Hirofumi Yoshino, Takashi Sakaguchi, Masaya Yonemori, Masafumi Tsuruda, Shunsuke Okamura, Hideki Enokida, Kazuki Kuroshima, Masayuki Nakagawa, Shuichi Tatarano, Yoichi Osako
Publikováno v:
BMC Cancer
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Background Cisplatin-based chemotherapy is recommended as the primary treatment for advanced bladder cancer (BC) with unresectable or metastatic disease. However, the benefits are limited due to the acquisition of drug resistance. The mechanisms of r
Autor:
Kee Ming Chia, Sarah Alexandrou, C. Elizabeth Caldon, Ensar Halilovic, Alexander Swarbrick, Rhiannon Coulson, Wayne D. Tilley, Heloisa Helena Milioli, Aliza Yong, Ygal Haupt, Neil Portman, Elgene Lim, Andrew Parker, Sue Haupt, Davendra Segara, Kristine J. Fernandez
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 22, Iss 1, Pp 1-17 (2020)
Breast Cancer Research, Vol 22, Iss 1, Pp 1-17 (2020)
BackgroundResistance to endocrine therapy is a major clinical challenge in the management of oestrogen receptor (ER)-positive breast cancer. In this setting, p53 is frequently wildtype and its activity may be suppressed via upregulation of its key re
Autor:
Takuma Higurashi, Tsutomu Yoshihara, Tomohiro Takatsu, Tetsuya Matsuura, Keiichi Ashikari, Hidenori Ohkubo, Noboru Misawa, Akiko Fuyuki, Jun Arimoto, Atsushi Nakajima
Publikováno v:
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-6 (2020)
BMC Cancer, Vol 20, Iss 1, Pp 1-6 (2020)
Background Leukotriene receptor antagonists (LTRAs) are broadly used for the management of allergic asthma and have recently been indicated to inhibit carcinogenesis and cancer cell growth. In colorectal cancer (CRC) chemoprevention studies, the occu
Autor:
Marek Michalak, Yongxiang Yi, Huang Yuan, Jingfeng Tang, Zhou Cefan, Qin Wenying, Yanan Yan, Rui Zhang, Xueying Dong, Xing-Zhen Chen, Jie Wei, Declan W. Ali, Changhua Yi, Xuewen Zhang
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 19, Iss 1, Pp 1-24 (2020)
Molecular Cancer, Vol 19, Iss 1, Pp 1-24 (2020)
Background Pancreatic cancer is one of the most lethal malignancies and has an extremely poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major challenge. The long noncoding RNA PVT1 was reported to be involved in
Autor:
Yoshinori Hosoya, Kotaro Yoshimura, Koji Koinuma, Yasunaru Sakuma, Naohiro Sata, Hideyuki Ohzawa, Hisanaga Horie, Hidenori Tsukui, Joji Kitayama, Alan Kawarai Lefor, Hironori Yamaguchi
Publikováno v:
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
Background Anti-tumor effects of radiation therapy (RT) largely depend on host immune function. Adenosine with its strong immunosuppressive properties is an important immune checkpoint molecule. Method We examined how intra-tumoral adenosine levels m
Autor:
Zhou Tong, Cong Yan, Hangyu Zhang, Weijia Fang, Yi Zheng, Guoqing Zhang, Liyun Yuan, Lulu Liu, Peng Zhao, Qihan Fu, Weiqin Jiang, Jinming Cheng
Publikováno v:
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Background KRAS mutations have been characterized as the major predictive biomarkers for resistance to cetuximab treatment. However, studies indicate that not all KRAS mutations are associated with equivalent treatment outcomes. KRAS G13D mutations w