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Autor:
Ioannis Parodis, Andreas Jönsen, Iva Gunnarsson, Christopher Sjöwall, Azita Sohrabian, Nellie Carlströmer-Berthén, Anders A. Bengtsson, Agneta Zickert, Martina Frodlund, Johan Rönnelid
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-15 (2019)
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-15 (2019)
Introduction Immune complexes are of importance in systemic lupus erythematosus pathogenesis, and autoantibodies are believed to participate in immune complex formation. Quantification of autoantibody levels in circulating IC might be of prognostic v
Autor:
Jorge Chaves, Dongli Zhou, Alain Ravaud, Patrick Schöffski, Silke Guenther, John C. Morris, Nuria Kotecki, Ulka N. Vaishampayan, Marcis Bajars, Julio Peguero, Martin Smakal, Christian Borel, James L. Gulley
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
BACKGROUND: Antibodies targeting programmed death-1 (PD-1) or programmed death-ligand 1 (PD-L1) have shown clinical activity in the treatment of metastatic renal cell carcinoma (mRCC). This phase Ib cohort of the JAVELIN Solid Tumor trial assessed th
Autor:
Anup Sood, Fiona Ginty, Susan Perry, Ravi A. Madan, Stefania Pittaluga, Leomar Y. Ballester, Arun Rajan, Geraldine O'Sullivan Coyne, Kevin M. Chin, Lauren M. Lepone, Raffit Hassan, Eva Szabo, Stephen M. Hewitt, Renee N. Donahue, Jeffrey Schlom, James L. Gulley, Arlene Berman, Andrew L. Mammen, Yo-Ting Tsai, Anish Thomas, Christopher R. Heery, Udayan Guha
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Background Thymic epithelial tumors are PD-L1–expressing tumors of thymic epithelial origin characterized by varying degrees of lymphocytic infiltration and a predisposition towards development of paraneoplastic autoimmunity. PD-1–targeting antib
Autor:
Caixia Xu, Zhiheng Liao, Peiqiang Su, Anjing Liang, Yan Peng, Xudong Wang, Yongyong Li, Tongzhou Liang, Dongsheng Huang, Hang Zhou, Xiaoming Yang, Bo Gao, Yuanxin Zhu, Chengjie Lian, Jincheng Qiu, Xianjian Qiu
Publikováno v:
Molecular Medicine
Molecular Medicine, Vol 25, Iss 1, Pp 1-14 (2019)
Molecular Medicine, Vol 25, Iss 1, Pp 1-14 (2019)
Background The protective effect of melatonin against bone metabolism imbalance in osteoporosis (OP) induced by drugs such as retinoic acid (RA) is unclear. The aim of this study was to explore the role of melatonin in bone destruction based on a mou
Autor:
Jia En Wu, Shuenn Chen Yang, Kuo Yen Huang, Tse-Ming Hong, Keng Fu Hsu, Chao Jung Tsao, Si Xuan Chen, Yi Ying Wu, Yuh Ling Chen, Hung Chang Wu
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-16 (2019)
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-16 (2019)
Background Lung cancer is the most common cause of cancer-related mortality worldwide despite diagnostic improvements and the development of targeted therapies, notably including epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI
Autor:
André Haman, Noël J.-M. Raynal, Annie Beaudry, Moutih Rafei, Kolja Eppert, Yuka Sai, Serge McGraw, Elodie M. Da Costa, Jeffrey R. Johnson, Nevan J. Krogan, Trang Hoang, Chantal Richer, Daniel Sinnett, Meaghan Boileau, Ema Flores-Diaz, Pascal St-Onge, Christian Beauséjour, Maxime Caron, Gregory Armaos, Virginie Bertrand-Lehouillier, Gabrielle McInnes, Michael Downey, Gaël Moquin-Beaudry
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Background Cardiac glycosides are approved for the treatment of heart failure as Na+/K+ pump inhibitors. Their repurposing in oncology is currently investigated in preclinical and clinical studies. However, the identification of a specific cancer typ
Autor:
Sixi Wei, Ken Y. Yoneda, Ruiwu Liu, Randy P. Carney, Kevin Yang, Wenwu Xiao, Weijie Ma, Qianping Li, Joyce S Lee, Kit S. Lam, Tianhong Li, Alan Nyugen
Publikováno v:
Journal of Hematology & Oncology
Journal of hematology & oncology, vol 12, iss 1
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-18 (2019)
Journal of hematology & oncology, vol 12, iss 1
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-18 (2019)
Background α3β1 integrin is a promising cancer biomarker and drug target. We previously identified a 9-amino-acid cyclic peptide LXY30 for detecting α3β1 integrin on the surface of live tumor cells. This study was undertaken to characterize LXY30
Autor:
Hejian Zou, Jing Han, Jiucun Wang, Xiaodong Zhou, Hui Zhang, Jing Liu, John D. Reveille, Qi Zhu, Yuan Li, Shifang Ren, Yanyun Ma, Li Jin, Jianxin Gu, Dongyi He
Publikováno v:
Molecular Medicine
Molecular Medicine, Vol 25, Iss 1, Pp 1-7 (2019)
Molecular Medicine, Vol 25, Iss 1, Pp 1-7 (2019)
Background Tumor necrosis factor (TNF) blockers have a high efficacy in treating Ankylosing Spondylitis (AS), yet up to 40% of AS patients show poor or even no response to this treatment. In this paper, we aim to build an approach to predict the resp
Autor:
Bruce R. Lindgren, Kristin L.M. Boylan, Amy P.N. Skubitz, Keith M. Skubitz, Edward Y. Cheng, Jon D. Wilson
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-13 (2019)
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-13 (2019)
Background Cancer stem cells (CSC) may respond to chemotherapy differently from other tumor cells. Methods This study examined the expression of the putative cancer stem cell markers ALDH1, CD44, and CD133; the angiogenesis marker CD31; and the macro
Publikováno v:
World Journal of Emergency Surgery : WJES
World Journal of Emergency Surgery, Vol 14, Iss 1, Pp 1-8 (2019)
World Journal of Emergency Surgery, Vol 14, Iss 1, Pp 1-8 (2019)
Background Determining the presence of an active arterial hemorrhage in the acute phase is important as a treatment strategy in patients with pelvic fracture. The purpose of this study was to evaluate whether coagulation biomarkers could predict arte