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Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model
Autor:
Margaret Haberman, Michael W. Lawlor, Jennifer L. Strande, Ngoc Thien Lam, Rachel T. Sullivan, Muhammad Afzal, Margaret Beatka
Publikováno v:
BMC Cardiovascular Disorders
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-12 (2021)
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-12 (2021)
Background Duchenne muscular dystrophy (DMD) associated cardiomyopathy is a major cause of morbidity and mortality. In an in vitro DMD cardiomyocyte model, nicorandil reversed stress-induced cell injury through multiple pathways implicated in DMD. We
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-13 (2020)
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-13 (2020)
Background The loss of locus coeruleus noradrenergic (LC/NE) neurons in the brainstem is reported in multiple neurodegenerative disorders, including Parkinson’s disease (PD). However, the mechanisms remain unclear. Strong evidence suggested that mi
Autor:
Holly T. Philpott, Jason J. McDougall
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-9 (2020)
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-9 (2020)
Background Endocannabinoids are showing great promise as effective mediators for controlling joint inflammation and pain. One strategy that could be harnessed to promote endogenous cannabinoid function is to inhibit the enzymatic break down of endoca
Autor:
Jorge Chaves, Dongli Zhou, Alain Ravaud, Patrick Schöffski, Silke Guenther, John C. Morris, Nuria Kotecki, Ulka N. Vaishampayan, Marcis Bajars, Julio Peguero, Martin Smakal, Christian Borel, James L. Gulley
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
BACKGROUND: Antibodies targeting programmed death-1 (PD-1) or programmed death-ligand 1 (PD-L1) have shown clinical activity in the treatment of metastatic renal cell carcinoma (mRCC). This phase Ib cohort of the JAVELIN Solid Tumor trial assessed th
Autor:
Anup Sood, Fiona Ginty, Susan Perry, Ravi A. Madan, Stefania Pittaluga, Leomar Y. Ballester, Arun Rajan, Geraldine O'Sullivan Coyne, Kevin M. Chin, Lauren M. Lepone, Raffit Hassan, Eva Szabo, Stephen M. Hewitt, Renee N. Donahue, Jeffrey Schlom, James L. Gulley, Arlene Berman, Andrew L. Mammen, Yo-Ting Tsai, Anish Thomas, Christopher R. Heery, Udayan Guha
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Background Thymic epithelial tumors are PD-L1–expressing tumors of thymic epithelial origin characterized by varying degrees of lymphocytic infiltration and a predisposition towards development of paraneoplastic autoimmunity. PD-1–targeting antib
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Chemotherapy-induced cognitive impairment (CICI) is a commonly reported neurotoxic side effect of chemotherapy, occurring in up to 75% cancer patients. CICI manifests as decrements in working memory, executive functioning, attention, and processing s
Autor:
Hiranya Pintana, Massimo Collino, Thomas Klein, Harald Tammen, Thomas Nyström, Fausto Chiazza, Grazyna Lietzau, Cesare Patrone, Vladimer Darsalia
Publikováno v:
Cardiovascular Diabetology
Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-13 (2018)
Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-13 (2018)
Background Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) are approved drugs for the treatment of hyperglycemia in patients with type 2 diabetes. These effects are mainly mediated by inhibiting endogenous glucagon-like peptide-1 (GLP-1) cleavag
Autor:
Zhirui Guo, Shaoang Tu, Jian-Hui Liang, Shasha Xu, Xingdang Liu, Jinlong Gao, Jinming Zhang, Jia Liu, Mei Han, Yiyun Huang
Publikováno v:
BMC Complementary and Alternative Medicine
BMC Complementary and Alternative Medicine, Vol 18, Iss 1, Pp 1-11 (2018)
BMC Complementary and Alternative Medicine, Vol 18, Iss 1, Pp 1-11 (2018)
Background Methamphetamine (METH) is a psychostimulant with high abuse liability that affects the monoamine neurotransmitter systems, particularly the dopamine system. Currently there are no effective medications for the treatment of METH abuse to re
Autor:
Li Ping Tang, Peter A. Sloane, Emily Falk Libby, Lawrence Rasmussen, S. Vamsee Raju, Steven M. Rowe
Publikováno v:
Respiratory Research
Respiratory Research, Vol 18, Iss 1, Pp 1-8 (2017)
Respiratory Research, Vol 18, Iss 1, Pp 1-8 (2017)
Background Dysfunction in cystic fibrosis transmembrane conductance regulator (CFTR) can be elicited by cigarette smoke and is observed in patients with chronic bronchitis. We have previously demonstrated in human airway epithelial cell monolayers th
Autor:
Ritushree Kukreti, Manish Mishra, Shrikant Kukreti, Chitra Rawat, Puneet Talwar, Suman Kushwaha, Debleena Guin
Publikováno v:
BMC Medical Genomics
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-21 (2017)
BMC Medical Genomics, Vol 10, Iss 1, Pp 1-21 (2017)
Background PD is a progressive neurodegenerative disorder commonly treated by levodopa. The findings from genetic studies on adverse effects (ADRs) and levodopa efficacy are mostly inconclusive. Here, we aim to identify predictive genetic biomarkers