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Publikováno v:
Molecular Autism
Molecular Autism, Vol 9, Iss 1, Pp 1-13 (2018)
Molecular Autism, Vol 9, Iss 1, Pp 1-13 (2018)
Background Gut microbiota has the capacity to impact the regular function of the brain, which can in turn affect the composition of microbiota. Autism spectrum disorder (ASD) patients suffer from gastrointestinal problems and experience changes in gu
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-11 (2018)
Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-11 (2018)
Background Morphine is widely used in clinical practice for a class of analgesic drugs, long-term use of morphine will cause the action of tolerance. MicroRNAs have been reported to be involved in morphine analgesic tolerance.. Methods Forty male SD
Publikováno v:
Journal of Biomedical Science
Background Recently, NAD+ has been considered as an essential factor, participating in nerve control of physiological functions and intercellular communication. NAD+ also has been supposed as endogenous activator of P1 and P2 purinoreceptors. Effects
Autor:
Wolfgang Drommer, Catrin Albrecht, Paul Borm, Irene M. J. Eurlings, Niki L. Reynaert, Roel P. F. Schins, Timothy N. Perkins, Paul Peeters, Emiel F.M. Wouters
Publikováno v:
Particle and Fibre Toxicology
Particle and Fibre Toxicology, 11(1):58. BioMed Central Ltd
Particle and Fibre Toxicology, 11(1):58. BioMed Central Ltd
Rationale Mineral particles in the lung cause inflammation and silicosis. In myeloid and bronchial epithelial cells the inflammasome plays a role in responses to crystalline silica. Thioredoxin (TRX) and its inhibitory protein TRX-interacting protein
Publikováno v:
Journal of Biomedical Science
Background An endogenous dopaminergic (DA) tone acting on D3 receptors has been shown to inhibit tuberoinfundibular (TI) DA neuron activity and stimulate prolactin (PRL) surge in the afternoon of estrogen-primed ovariectomized (OVX+E2) rats. Whether
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 19, Iss 1, p 48 (2012)
Journal of Biomedical Science, Vol 19, Iss 1, p 48 (2012)
Background Whereas brain death is a vitally important clinical phenomenon, our contemporary understanding on its underlying cellular mechanisms remains elusive. This study evaluated whether the ubiquitin-proteasome system (UPS) in the rostral ventrol
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 18, Iss 1, p 31 (2011)
Journal of Biomedical Science, Vol 18, Iss 1, p 31 (2011)
Background- Hypoxia during the first week of life can induce neuronal death in vulnerable brain regions usually associated with an impairment of cognitive function that can be detected later in life. The neurobiological changes mediated through neuro
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 17, Iss Suppl 1, p S16 (2010)
Journal of Biomedical Science, Vol 17, Iss Suppl 1, p S16 (2010)
Background Poly(ADP-ribose) is a NAD+-requiring, DNA-repairing, enzyme playing a central role in pancreatic β-cell death and in the development of endothelial dysfunction in humans and experimental animals. PARP activation is also relevant to the de
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 16, Iss 1, p 99 (2009)
Journal of Biomedical Science, Vol 16, Iss 1, p 99 (2009)
Metabotrophic glutamate receptors (mGluRs) modulate cellular activities involved in the processes of differentiation and degeneration. In this study, we have analysed the expression pattern of group-I metabotropic glutamate receptor (mGlu-5) in cereb
Publikováno v:
Molecular Brain
Molecular Brain, Vol 1, Iss 1, p 13 (2008)
Molecular Brain, Vol 1, Iss 1, p 13 (2008)
Background Although long-term potentiation (LTP) of synaptic strength is very persistent, current studies have provided evidence that various manipulations or pharmacological treatment when applied shortly after LTP induction can reverse it. This kin