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Autor:
Holly T. Philpott, Jason J. McDougall
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-9 (2020)
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-9 (2020)
Background Endocannabinoids are showing great promise as effective mediators for controlling joint inflammation and pain. One strategy that could be harnessed to promote endogenous cannabinoid function is to inhibit the enzymatic break down of endoca
Autor:
Chun Wang, Lin Wang, Yucong Peng, Jianru Li, Jingsen Chen, Cheng Wu, Sheng Nie, Linfeng Fan, Zhi-jiang Wang, Gao Chen, C. Charles Gu, Jingyin Chen, Hangzhe Xu, Feng Yan
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-14 (2017)
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-14 (2017)
Background The NLRP3 inflammasome is a multiprotein complex that regulates the innate immune inflammatory response by activating caspase-1 and subsequent IL-1β and IL-18. Fluoxetine has been shown to have the anti-inflammatory properties in many dis
Autor:
Chao Meng, David Montani, Dongmin Shao, Stephen J. Wort, Frédéric Perros, Jie Zhu, Marc Humbert, Peter Dorfmüller, Benjamin Garfield, Ian M. Adcock, Laura C. Price
Publikováno v:
Respiratory Research
Background Dexamethasone suppressed inflammation and haemodynamic changes in an animal model of pulmonary arterial hypertension (PAH). A major target for dexamethasone actions is NF-κB, which is activated in pulmonary vascular cells and perivascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebde3506a829f833c64b3bfbd70e8f19
http://hdl.handle.net/10044/1/26288
http://hdl.handle.net/10044/1/26288
Publikováno v:
Journal of Neuroinflammation
Background Motor cortex stimulation (MCS) is an effective treatment in neuropathic pain refractory to pharmacological management. However, analgesia is not satisfactorily obtained in one third of patients. Given the importance of understanding the me
Autor:
Grant R. Zimmermann, William Avery, Finelli Alyce Lynn, Alexis Borisy, Melissa Farwell, Christopher C Fraser
Publikováno v:
Arthritis Research & Therapy
Introduction Glucocorticoids are a mainstay of anti-inflammatory therapy, but significant adverse effects ultimately limit their utility. Previous efforts to design glucocorticoid structures with an increased therapeutic window have focused on dissoc
Autor:
Anita Conforti, Flavia Chiarotti, Francesca Menniti-Ippolito, Paolo Bellavite, Roberto Raschetti, S. Bertani
Publikováno v:
BMC Complementary and Alternative Medicine
BMC Complementary and Alternative Medicine, Vol 7, Iss 1, p 1 (2007)
BMC Complementary and Alternative Medicine, Vol 7, Iss 1, p 1 (2007)
Background One of the cardinal principles of homeopathy is the "law of similarities", according to which patients can be treated by administering substances which, when tested in healthy subjects, cause symptoms that are similar to those presented by