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Autor:
Sergio Wittlin, Shridhar Narayanan, Vijay Potluri, Ganesh Sambasivam, R. Gavara, Radha Shandil, Brice Campo
Publikováno v:
Malaria Journal
Malaria Journal, Vol 19, Iss 1, Pp 1-15 (2020)
Malaria Journal, Vol 19, Iss 1, Pp 1-15 (2020)
Background Emergence of anti-malarial drug resistance and perpetual increase in malaria incidence necessitates the development of novel anti-malarials. Histone deacetylases (HDAC) has been shown to be a promising target for malaria, despite this, the
Publikováno v:
BMC Complementary Medicine and Therapies
BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-12 (2020)
BMC Complementary Medicine and Therapies, Vol 20, Iss 1, Pp 1-12 (2020)
Background Citrus plants particularly lemon (Citrus limon L.) concoctions are ethno-medically used for treatment of infectious diseases including malaria. Therefore, we set an experiment to investigate the effects of lemon decoction in mice infected
Publikováno v:
Malaria Journal
Malaria Journal, Vol 17, Iss 1, Pp 1-12 (2018)
Malaria Journal, Vol 17, Iss 1, Pp 1-12 (2018)
Background Tafenoquine was recently approved for Plasmodium vivax radical cure (KRINTAFEL™) and malaria prevention (ARAKODA™). Methods A review of the non-clinical and clinical literature was conducted to assess whether tafenoquine (and primaquin
Publikováno v:
Malaria Journal
MALARIA JOURNAL(16)
MALARIA JOURNAL(16)
Background The widespread emergence of anti-malarial drug resistance has necessitated the discovery of novel anti-malarial drug candidates. In this study, chloroquine derivatives were evaluated for the improved anti-malarial activity. Results Novel t
Publikováno v:
Malaria Journal
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Background: Artemisinin-based combination therapy (ACT) has been adopted as national policy for the first-line treatment in large number of malaria-endemic regions. However, artemisinin-resistant parasites have emerged and are sp
Background: Artemisinin-based combination therapy (ACT) has been adopted as national policy for the first-line treatment in large number of malaria-endemic regions. However, artemisinin-resistant parasites have emerged and are sp
Autor:
Steve A. Ward, Kevin Marsh, Leah Mwai, Philip Sasi, Edwin Ochong, Alexis Nzila, Steven M. Kiara, Gilbert Kokwaro, Margaret J. Mackinnon, Steffen Borrmann, Abdi Abdirahman
Publikováno v:
Malaria Journal, Vol 8, Iss 1, p 106 (2009)
Malaria Journal
Malaria Journal
Background The spread of resistance to chloroquine (CQ) led to its withdrawal from use in most countries in sub-Saharan Africa in the 1990s. In Malawi, this withdrawal was followed by a rapid reduction in the frequency of resistance to the point wher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc77cecfc090aafed26abe16c15c421
https://ora.ox.ac.uk/objects/uuid:bce2c24c-5748-4ca3-a532-3f5de141516d
https://ora.ox.ac.uk/objects/uuid:bce2c24c-5748-4ca3-a532-3f5de141516d
Autor:
Liem Hui Ling, Rianto Setiabudy, Dedeh Endawati, J. Kevin Baird, Ferdinand Laihad, Inge Sutanto
Publikováno v:
Malaria Journal, Vol 9, Iss 1, p 52 (2010)
Malaria Journal
Malaria Journal
Background Chloroquine was used as first-line treatment for Plasmodium falciparum or Plasmodium vivax in Indonesia before the initial launch of artemisinin combination therapy in 2004. A study to evaluate efficacies of chloroquine against P. falcipar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8484a94a0281714cd2070ef8314b031
https://ora.ox.ac.uk/objects/uuid:7dfe960b-fab2-41fd-8155-3312c90cd0a0
https://ora.ox.ac.uk/objects/uuid:7dfe960b-fab2-41fd-8155-3312c90cd0a0
Autor:
Delves, MJ, Sinden, RE
Publikováno v:
Malaria Journal
Malaria Journal, Vol 9, Iss 1, p 35 (2010)
Malaria Journal, Vol 9, Iss 1, p 35 (2010)
Background Malaria transmission is now recognized as a key target for intervention. Evaluation of the Plasmodium oocyst burden in the midguts of Anopheles spp. is important for many of assays investigating transmission. However, current assays are ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1823556beb943eacc7a83e06926e79
https://ora.ox.ac.uk/objects/uuid:75dfd9ae-adf7-47bd-8c21-582e0c4cad7c
https://ora.ox.ac.uk/objects/uuid:75dfd9ae-adf7-47bd-8c21-582e0c4cad7c
Autor:
Mifong Tam, Neda Moradin, Anny Fortin, Sabrina Torre, Mary M. Stevenson, Jalal Hawari, Bart De Spiegeleer, Kirsten Vandercruyssen, Susan A. Gauthier, Philippe Gros
Publikováno v:
Malaria Journal
Background The potential emergence and spread of resistance to artemisinins in the Plasmodium falciparum malaria parasite constitutes a major global health threat. Hence, improving the efficacy of artemisinins and of artemisinin-based combination the
Autor:
Roberto R. Moraes Barros, Whitney A. Kite, Thomas E. Wellems, Viviana A. Melendez-Muniz, Juliana M. Sá
Publikováno v:
Malaria Journal
Background Artemisinin-based combination therapy is recommended to treat Plasmodium falciparum worldwide, but observations of longer artemisinin (ART) parasite clearance times (PCTs) in Southeast Asia are widely interpreted as a sign of potential ART