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Publikováno v:
CNS & Neurological Disorders - Drug Targets. 14:370-377
An increasing number of studies have demonstrated that insulin-degrading enzyme (IDE) plays an essential role in both the degradation and its activity of β-amyloid (Aβ). Therefore, the regulation of IDE expression and/or modification of IDE-depende
Publikováno v:
Protein & Peptide Letters. 22:180-192
Mesial temporal lobe epilepsy (MTLE) is the most prevalent form of refractory symptomatic epilepsy, most patients with MTLE respond poorly to anti-epileptic drugs (AEDs). The pathophysiological mechanism of MTLE remains unclear, blocking the path to