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Publikováno v:
CNS & Neurological Disorders - Drug Targets. 15:927-934
Erythropoietin (EPO) has been shown to be a key cytokine in the production of erythrocytes from erythroblasts. Recently, attempts have been made to adopt EPO as a drug target for neuroprotection in selected neurological pathologies. In the current st
Publikováno v:
Current Neuropharmacology
Rats emit high-frequency 50-kHz ultrasonic vocalizations (USV) in appetitive situations like social interactions. Drugs of abuse are probably the most potent non-social elicitors of 50-kHz USV, possibly reflecting their euphorigenic properties. Psych
Autor:
Yumei Wang, Richard P. E. van Dokkum, Sjoerd W. Landheer, Hendrik Buikema, Robert H. Henning, Peter Vavrinec, Leo E. Deelman
Publikováno v:
Current Vascular Pharmacology, 12(6), 836-844. BENTHAM SCIENCE PUBL LTD
Type 2 diabetes mellitus (T2DM) is associated with risk for chronic kidney disease (CKD), which is associated with a decrease in renal myogenic tone - part of renal autoregulatory mechanisms. Novel class of drugs used for the treatment of T2DM, dipep
Autor:
Forough Sanaee, Fakhreddin Jamali
Publikováno v:
Current Pharmaceutical Design. 20:1311-1317
Inflammation reduces pharmacological response to β1-blockers by down-regulating the target receptor protein. This may contribute to the sub-optimal response to pharmacotherapy with β-blockers. Nebivolol is a third generation β-adrenoceptor (AR) bl
Publikováno v:
Current Hypertension Reviews. 9:93-98
Recent studies have suggested that blood-brain barrier (BBB) abnormalities are present from an early stage in patients exhibiting mild symptoms of cognitive impairment during the development of hypertension. There is also growing body of evidence sug
Autor:
Ralf Hausmann, Günther Schmalzing
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 11:675-686
P2X receptors are homo- or heterotrimeric ATP-gated cation channels that assemble from seven subunits, P2X1-P2X7. To our knowledge, no drug that acts on the P2X1 or P2X2 receptors in the CNS or elsewhere in the body has been approved, nor is there su
Publikováno v:
Current Medicinal Chemistry. 19:3044-3057
Tryptamine (T) and several T derivatives (Ts) inhibit in a voltage-dependent manner the NMDA receptor (NR). This effect is influenced by substituents at various positions, but has not yet been subjected to a detailed SAR study. Here, 64 Ts have been
Publikováno v:
Current Topics in Medicinal Chemistry. 11:1128-1150
Sigma receptors have been well documented as a protein target for cocaine and have been shown to be involved in the toxic and stimulant actions of cocaine. Strategies to reduce the access of cocaine to sigma receptors have included antisense oligonuc
Publikováno v:
Current Topics in Medicinal Chemistry. 11:1012-1033
Nucleosides, such as uridine, inosine, guanosine and adenosine, may participate in the regulation of sleep, cognition, memory and nociception, the suppression of seizures, and have also been suggested to play a role in the pathophysiology of some neu
Autor:
Detlev Boison
Publikováno v:
Current Topics in Medicinal Chemistry. 11:1068-1086
Nucleoside receptors are known to be important targets for a variety of brain diseases. However, the therapeutic modulation of their endogenous agonists by inhibitors of nucleoside metabolism represents an alternative therapeutic strategy that has ga