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Publikováno v:
Current Topics in Medicinal Chemistry. 11:1012-1033
Nucleosides, such as uridine, inosine, guanosine and adenosine, may participate in the regulation of sleep, cognition, memory and nociception, the suppression of seizures, and have also been suggested to play a role in the pathophysiology of some neu
Autor:
Detlev Boison
Publikováno v:
Current Topics in Medicinal Chemistry. 11:1068-1086
Nucleoside receptors are known to be important targets for a variety of brain diseases. However, the therapeutic modulation of their endogenous agonists by inhibitors of nucleoside metabolism represents an alternative therapeutic strategy that has ga
Publikováno v:
Current Molecular Medicine. 3:419-426
An increasing body of evidence suggests that the muscarinic receptors may present a potential therapeutic target for the treatment of schizophrenia. This argument is supported by studies using postmortem CNS tissue and a neuroimaging study that have