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Autor:
Yumei Wang, Richard P. E. van Dokkum, Sjoerd W. Landheer, Hendrik Buikema, Robert H. Henning, Peter Vavrinec, Leo E. Deelman
Publikováno v:
Current Vascular Pharmacology, 12(6), 836-844. BENTHAM SCIENCE PUBL LTD
Type 2 diabetes mellitus (T2DM) is associated with risk for chronic kidney disease (CKD), which is associated with a decrease in renal myogenic tone - part of renal autoregulatory mechanisms. Novel class of drugs used for the treatment of T2DM, dipep
Autor:
Forough Sanaee, Fakhreddin Jamali
Publikováno v:
Current Pharmaceutical Design. 20:1311-1317
Inflammation reduces pharmacological response to β1-blockers by down-regulating the target receptor protein. This may contribute to the sub-optimal response to pharmacotherapy with β-blockers. Nebivolol is a third generation β-adrenoceptor (AR) bl
Publikováno v:
Current Medicinal Chemistry. 19:3044-3057
Tryptamine (T) and several T derivatives (Ts) inhibit in a voltage-dependent manner the NMDA receptor (NR). This effect is influenced by substituents at various positions, but has not yet been subjected to a detailed SAR study. Here, 64 Ts have been
Publikováno v:
Current Topics in Medicinal Chemistry. 11:1128-1150
Sigma receptors have been well documented as a protein target for cocaine and have been shown to be involved in the toxic and stimulant actions of cocaine. Strategies to reduce the access of cocaine to sigma receptors have included antisense oligonuc
Publikováno v:
Current Topics in Medicinal Chemistry. 11:1012-1033
Nucleosides, such as uridine, inosine, guanosine and adenosine, may participate in the regulation of sleep, cognition, memory and nociception, the suppression of seizures, and have also been suggested to play a role in the pathophysiology of some neu