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Autor:
Huijing Zhu, Li Yan, Weiqi Min, Ruihuan Zhang, Yiheng Chen, Ying Li, Min Cai, Jun Wang, Chunhua Wang
Publikováno v:
Current Topics in Medicinal Chemistry. 21:2425-2433
Background and Objective: Osteoporosis is a worldwide healthcare challenge. Conventional medications for osteoporosis prevention are not clinically effective or associated with gastrointestinal tract adverse effects. The present study aimed to compar
Autor:
Siva G Somasundaram, Denis V Kasatkin, Gjumrakch Aliev, Cecil E Kirkland, Narasimha M Beeraka, Elizaveta V Mikhaylenko, Sergey V Dindyaev
Publikováno v:
Current Pharmaceutical Design. 27:3061-3073
Background: Biogenic amines (BAs) secreted by the sympathetic neural apparatus of rat uterus are reported to be conducive to the uterine functional activity during postpartum involution; the imbalance in BAs ratio could confer postpartum reproductive
Autor:
Mahshid Alimohammadi, Seyedeh-Sara Hashemi, Mohammad Javad Khoshnoud, Bahman Khalvati Fahlyan, Zahra Sabahi, Marzieh Rashedinia
Publikováno v:
Current Drug Discovery Technologies. 18:405-413
Background: Diabetic nephropathy can lead to renal diseases; oxidative stress and mitochondrial dysfunction have critical roles in its development. Objectives: In this study, the effect of syringic acid (SYR), a natural phenolic acid, on diabetic nep
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:458-463
Background: Cisplatin is a chemotherapeutic drug used to treat testicular cancer that induces testicular toxicity. This study aimed to investigate the possible role of androgens, androgen receptor, and organic cation transporter 2 (OCT2) in the prote
Autor:
Hani Al-Salami, Frank Arfuso, Momir Mikov, Armin Mooranian, Bozica Kovacevic, Ryu Takechi, Giuseppe Luna, Svetlana Goločorbin-Kon, Nassim Zamani
Publikováno v:
Current Diabetes Reviews. 16:900-909
Background: Recent studies have suggested that hyperglycaemia influences the bile acid profile and concentrations of secondary bile acids in the gut. Introduction: This study aimed to measure changes in the bile acid profile in the gut, tissues, and
Autor:
Zhengjun Chen, Chenfeng Qiu, Qian Zhu, Xiaomin Ma, Jinwei Yang, Xuewen Feng, Xiaoxiao Tao, Xianjun Bao, Weilin Wu
Publikováno v:
Current Pharmaceutical Biotechnology. 21:702-709
Objective: The purpose of this paper was to study the protective effect of paeoniflorin on acute cerebral ischemia. The animal model of cerebral infarction induced by Middle Cerebral Artery Occlusion (MCAO) was blocked by the suture method. Sixty SD
Publikováno v:
Current Gene Therapy. 19:211-215
Objective: The objective of the research is to investigate the effects of Huangkui capsule on the expression of SPARC in the kidney tissues of diabetic nephropathy. Methods: SD rats were divided into three groups: normal control group, untreated DN g
Publikováno v:
Current Pharmaceutical Design. 25:3257-3265
Background: Many diseases can be treated with metformin. People with serum thyrotropin (TSH) levels higher than 10 mIU/L are at a risk of cardiovascular events. Some studies have suggested that metformin can lower serum TSH levels to a subnormal leve
Autor:
Ozlem Ozmen, Senay Topsakal
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 19:1141-1147
Objective: The aim of this study was to examine pancreatic pathology and the prophylactic effects of pregabalin in lipopolysaccharide (LPS) induced sepsis model in aged rats. Methods: Twenty-four female, one-year-old, Wistar Albino rats were assigned
Publikováno v:
Current Neuropharmacology
We examined the influence of adrenalectomy on NSAID-induced small intestinal damage in rats and investigated the possible involvement of adrenal glucocorticoids in the protective effects of urocortin I, a corticotropin-releasing factor (CRF) agonist.