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Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:1431-1440
Background: One of the widely spread disorders is Diabetes mellitus, especially type 2 (T2DM). T2DM is attributed to the change in life style and stress. A possible strategy to block dietary carbohydrate absorption is regulation of postprandial blood
Autor:
Li Zheng
Publikováno v:
Current Pharmaceutical Biotechnology. 22:1538-1545
Background: Although Semaphorin 3A (Sema3A)/ Neuropilin-1(NRP1)/Plexin A1 is one of the important targets in bone metabolism, few studies are performed on this target in the glucocorticoids- induced osteoporosis. Luteolin is a chemical component of H
Autor:
Azam Hosseinzadeh, Iman Fatemi, Saeed Mehrzadi, Ehsan Dehdashtian, Mohammad Yahya Karimi, Karim Hemati
Publikováno v:
Central Nervous System Agents in Medicinal Chemistry. 21:125-129
Background: Epilepsy, the second most frequent neurological disease, is a chronic disorder with a high lifetime prevalence. Therefore, various studies are needed to find new effective therapeutic agents to treat seizures or prevent their complication
Publikováno v:
Current Diabetes Reviews. 18
Painful diabetic peripheral neuropathy (painful-DPN) is a highly prevalent and disabling condition, affecting up to one-third of patients with diabetes. This condition can have a profound impact resulting in a poor quality of life, disruption of empl
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:458-463
Background: Cisplatin is a chemotherapeutic drug used to treat testicular cancer that induces testicular toxicity. This study aimed to investigate the possible role of androgens, androgen receptor, and organic cation transporter 2 (OCT2) in the prote
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:526-533
Background and Objective: All three isoforms of nitric oxide (NO) synthase (NOS) are targets for thyroid hormones in the cardiovascular system. The aim of this study was to assess the effects of hypo- and hyperthyroidism on inducible (iNOS), endothel
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:352-359
Background: Endothelial nitric oxide synthase (eNOS) plays a major role in the response of anti-hypercholesterol statin drugs. Genetic polymorphisms in the eNOS gene affect the activity of eNOS thereby modulating the statin response. Objectives: This
Publikováno v:
Current Neurovascular Research. 17:510-517
Background: Hypoxic-ischemic encephalopathy (HIE) is a major cause of pediatric and adult mortality and morbidity. Unfortunately, to date, no effective treatment has been identified. In the striatum, neuronal injury is analogous to the cellular mecha
Autor:
Saleh Mohammed Abdullah, Hina Rashid
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 20:1321-1327
Background: Bisphenol A (BPA) is a xenobiotic that causes oxidative stress in various organs in living organisms. Blood cells are also an endpoint where BPA is known to cause oxidative stress. Blood cells, especially red blood cells (RBCs), are cruci
Publikováno v:
Curr Pharm Des
Background: We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction. Based on previous studies showing a critical role for the adenosine A2B receptor (ADORA2B) in PER2 regulation, we hyp