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Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:2048-2062
Apoptosis is a programmed cell death that occurs due to the production of several catabolic enzymes. During this process, several morphological and biochemical changes occur in mitochondria, the main organelle in the cell that participates in apoptos
Publikováno v:
Current Medicinal Chemistry. 28:8480-8495
The oxidative stress response is critical for malignant cells. It plays a dual role by helping cancer cells survive and proliferate but also causing apoptosis and apoptosis-- like cell death. The oxidative stress response is characterized by tight re
Publikováno v:
Current Stem Cell Research & Therapy. 16:824-839
The Hippo pathway, with its core components and the downstream transcriptional coactivators, controls the self-renewable capacity and stemness features of stem cells and serves as a stress response pathway by regulating proliferation, differentiation
Publikováno v:
Protein & Peptide Letters. 28:382-387
Transmembrane protein 166 (TMEM166) is a lysosomal/endoplasmic reticulum (ER)-associated protein found in different species where it functions as a regulator of programmed cell death through autophagy and apoptosis. It is expressed in a variety of no
Publikováno v:
Current Protein & Peptide Science. 21:860-877
Background: Stroke is one of the causes of death and disability globally. Brain attack is because of the acute presentation of stroke, which highlights the requirement for decisive action to treat it. Objective: The mechanism and in-vivo experimental
Autor:
Abdullah F. Alasmari, Ashok Kumar, Mohammad Waseem, A A Mohamed Adil, Neesar Ahmed, Shabnam Ameenudeen, Mohammad Aashique, S. Hemalatha, Nemat Ali
Publikováno v:
Current Pharmaceutical Design. 26:485-491
Mitochondria are the crucial regulators for the major source of ATP for different cellular events. Due to damage episodes, mitochondria have been established for a plethora ofalarming signals of stress that lead to cellular deterioration, thereby cau
Publikováno v:
Current Pharmaceutical Design. 25:2584-2594
Mitochondria are the central power stations of the cell involved with a myriad of cell signalling pathways that contribute for whole health status of the cell. It is a well known fact that not only mitochondrial genome encodes for mitochondrial prote
Autor:
Angela Isabel Pereira Eugênio, Gisele W. B. Colleoni, Luiz Felipe G. Sanson, Mariana Bleker de Oliveira, Rebecca S S Barbosa-Dantas
Publikováno v:
Current Molecular Medicine. 19:112-119
Introduction:Multiple myeloma (MM) cells accumulate in the bone marrow and produce enormous quantities of immunoglobulins, causing endoplasmatic reticulum stress and activation of protein handling machinery, such as heat shock protein response, autop
Publikováno v:
Current Pharmaceutical Design. 24:3176-3183
Initiating anti-apoptotic signaling or triggering cell death depends to a great extent on the nature or source of cellular stress and cell type. Interplay between each stress response eventually determines the fate of stressed cell. Numerous factors
Publikováno v:
Current Pharmaceutical Biotechnology. 19:644-663
Apoptosis, a form of programmed cell death, plays a very crucial role in various physiological processes for maintaining cell homeostasis. This process has several characteristic features like membrane blebbing, nuclear condensation, DNA fragmentatio