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Autor:
Snehasis Jana, Trupti Gohil, Upendra P. Lambe, Shyam Sundar Nandi, Sonali Ankush Sawant, Sudip Ghosh
Publikováno v:
Current Molecular Medicine. 22:594-607
Cluster of differentiation (CD155), formerly identified as poliovirus receptor (PVR) and later as immunoglobulin molecule, is involved in cell adhesion, proliferation, invasion and migration. It is a surface protein expressed mostly on normal and tra
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:2048-2062
Apoptosis is a programmed cell death that occurs due to the production of several catabolic enzymes. During this process, several morphological and biochemical changes occur in mitochondria, the main organelle in the cell that participates in apoptos
Publikováno v:
Current Molecular Medicine. 22:491-505
Exosomal vesicles enclose and carry a broad range of biological molecules, such as nucleic acids, lipids, and proteins, and transfer them between cells. In cancer, cells being mentioned could be neighbors in the same tumor microenvironment communicat
Autor:
Gholamreza Dehghan, Elham Kamalkazemi, Nader Sheibani, Fereydoon Abedi-Gaballu, Ali Mohammadi, Tala Farid Mohammad Hosseini, Behzad Mansoori, Behzad Baradaran
Publikováno v:
Kazemi, E K, Abedi-Gaballu, F, Mohammad Hosseini, T F, Mohammadi, A, Mansoori, B, Dehghan, G, Baradaran, B & Sheibani, N 2022, ' Glimpse into the Cellular Internalization and Intracellular Trafficking of Lipid-Based Nanoparticles in Cancer Cells ', Anti-Cancer Agents in Medicinal Chemistry, vol. 22, no. 10, pp. 1897-1912 . https://doi.org/10.2174/1871520621666210906101421
Lipid-based nanoparticles as drug delivery carriers have been mainly used for delivery of anti-cancer therapeutic agents. Lipid-based nanoparticles, due to their smaller particle size and similarity to cell membranes, are readily internalized into ca
Publikováno v:
Current Molecular Medicine. 22:287-299
Failure of embryo implantation has been introduced as an important limiting parameter in early assisted reproduction and pregnancy. The embryo-maternal interactions, endometrial receptivity, and detections of implantation consist of the embryo viabil
Autor:
Sukhes Mukherjee, Suman Kumar Ray
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1257-1271
Tissues are progressively molded by bidirectional correspondence between denizen cells and extracellular matrix (ECM) via cell-matrix connections along with ECM remodeling. The composition and association of ECM are spatiotemporally directed to contr
Publikováno v:
Current Medicinal Chemistry. 29:2399-2411
Epigenetic regulations play a crucial role in the expression of various genes that are important in the normal cell function. Any alteration in these epigenetic mechanisms can lead to the modification of histone and DNA, resulting in the silencing or
Autor:
Patricia Bogdanov, Hugo Ramos, Marta García-Ramírez, Jordi Huerta, Cristina Hernández, Rafael Simó, Olga Simó-Servat
Publikováno v:
Current Medicinal Chemistry. 29:2189-2199
Background: Ezrin, radixin, and moesin (the ERM complex) interact directly with membrane proteins regulating their attachment to actin filaments. ERM protein activation modifies cytoskeleton organization and alters the endothelial barrier function, t
Publikováno v:
Current Medicinal Chemistry. 29:2322-2333
The tricarboxylic acid (TCA) cycle is the center of energy metabolism in eukaryotic cells and is dynamically adjusted according to the energy needs of cells. Macrophages are activated by inflammatory stimuli, and then two breakpoints in TCA cycle lea
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:943-950
Background: Tyrosine Kinase Inhibitors (TKIs) can be used to inhibit cancer cell proliferation by targeting the vascular endothelial growth factor receptor (VEGFR) family. SAR131675 is a highly selective receptor tyrosine kinase inhibitor to VEGFR3 t