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Publikováno v:
Current Protein & Peptide Science. 22:548-558
Post Translational Modification (PTM) is a process in which covalent addition of functional groups on protein occurs to maintain their structure, function and stability. Every PTM process in our living system occurs to enhance the functional diversit
Autor:
Juan Peng, Qiong Xiang, Hui Ting Liu, Zhi‑Sheng Jiang, Zhi‑Han Tang, Jing Lin Zeng, Yiming Deng, Zhong Ren, Lu‑Shan Liu, Wen Feng Liu
Publikováno v:
Current Medicinal Chemistry. 28:7446-7460
Proprotein convertase subtilisin/Kexin type 9 (PCSK9) is a secretory serine protease that plays multiple biological functions in the regulation of physiological and pathological processes. PCSK9 inhibitors decrease the circulating LDL-cholesterol lev
Autor:
Tannaz Jamialahmadi, Thozhukat Sathyapalan, Armita Mahdavi Gorabi, Amirhossein Sahebkar, Mohsen Ghanbari
Publikováno v:
Current Drug Targets. 22:1738-1749
MicroRNAs (miRNAs) are non-coding RNAs containing around 22 nucleotides, which are expressed in vertebrates and plants. They act as posttranscriptional gene expression regulators, fine-tuning various biological processes in different cell types. Ther
Autor:
V. V. Malashchenko, Olga Khaziakhmatova, Maria Vulf, Daria Skuratovskaia, E. O. Shunkin, Aleksandra Komar, Larisa Litvinova, N. D. Gazatova
Publikováno v:
Current Pharmaceutical Design. 27:3105-3121
Background: Despite the great interest and numerous studies, there is currently no unified standard describing the sequential manipulation with cells to obtain exosomes for clinical use.The use of exosomes has become an attractive alternative to cell
Publikováno v:
Current Medicinal Chemistry. 28:5831-5846
Skeletal muscle atrophy has been characterized as a state of uncontrolled inflammation and oxidative stress that escalates protein catabolism. Recent advancement supports impinging signaling molecules in the muscle fibers controlled through toll-like
Publikováno v:
Current Stem Cell Research & Therapy. 16:656-669
Mesenchymal stromal cells (MSCs) have emerged as a modern development in therapeutics for a wide variety of diseases. Secreted paracrine factors constitute the principal components harboring the restorative promise of MSCs. Recent studies demonstrate
Publikováno v:
Current Drug Targets. 22:1376-1403
In neurodegenerative disorders, there is a progressive degeneration of the body, leading to the death of nerve cells. In this state, a patient gets affected day by day with mental weakness, dementia, and ataxia. Alzheimer’s disease (AD) is the most
Publikováno v:
Current Molecular Medicine. 21:347-353
Annexin, a calcium-dependent phospholipid-binding protein, can affect tumor cell adhesion, proliferation, apoptosis, invasion and metastasis, as well as tumor neovascularization in different ways. Recent studies have shown that annexin exists not onl
Publikováno v:
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 20:107-117
Background: Body defenses and metabolic processes probably co-evolved in such a way that rapid, energyintensive acute inflammatory repair is functionally integrated with energy allocation in a starvation/ infection / injury-prone primitive environmen
Autor:
Michael D. Dennis, Sadie K. Dierschke
Publikováno v:
Curr Diabetes Rev
Abstract:: It is well established that diabetes and its associated hyperglycemia negatively impacts retinal function, yet we know little about the role played by augmented flux through the hexosamine biosynthetic pathway (HBP). This offshoot of the g