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Publikováno v:
Current Protein & Peptide Science. 19:889-899
Leprosy is an infectious disease caused by non-cultivable bacteria Mycobacterium leprae. Ridley and Jopling classified the disease into five polar forms, Tuberculoid (TT) and Lepromatous (LL), in between two forms of the disease Borderline tuberculoi
Autor:
Pavel A. Galenko-Yaroshevsky, Marco Avila-Rodriguez, Vladimir N. Chubarev, Vadim V. Tarasov, Ekaterina T Bagaturiya, Susanna S Sologova, George E. Barreto, Gjumrakch Aliev, Andrey A. Svistunov, Svetlana A. Shakhmardanova
Publikováno v:
Current Protein & Peptide Science. 19:924-934
Urotensin II (UT II) is an important factor of cellular homeostasis. This regulatory peptide is involved in the pathophysiology of many disorders. For example, it plays an important role in the pathogenesis of acute and chronic diseases, stressful an
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 17:261-266
Background & Objective: The lysosome is a membrane-enclosed organelle widely found in every eukaryotic cell. It has been deemed as the stomach of the cells. Recent studies revealed that it also functions as an intracellular calcium store and is a pla
Publikováno v:
Current Drug Targets. 19:1077-1086
Heart failure represents a challenging clinical and public health problem and is associated with significant morbidity and mortality. Mechanistically, loss of cardiomyocytes leads to decompensated ventricular remodeling, which eventually progresses t
Autor:
Alba Minelli, Ilaria Bellezza, Silvia Grottelli, Matthew J. Peirce, Egidia Costanzi, Barbara Cellini
Publikováno v:
Current Protein & Peptide Science. 19:805-812
Protein function is dependent on assumption of the correct three-dimensional structure, achieved through the folding process. As a central element in ensuring cellular homeostasis, proteostasis i.e. the control of correct protein folding, trafficking
Publikováno v:
Current Cancer Drug Targets. 18:514-521
Currently Cancer is the leading cause of death worldwide. Malignancy or cancer is a class of diseases characterized by uncontrolled cell growth that eventually invade other tissues and develop secondary malignant growth at other sites by metastasis.
Publikováno v:
Current Drug Targets. 19:973-985
Background Mitochondrial aconitase (Aco2), a member of the family of iron-sulfur [4Fe- 4S]-containing dehydratases, is involved in cellular metabolism through the tricarboxylic acid cycle. Aco2 is highly susceptible to oxidative damage in a way that
Publikováno v:
Current Protein & Peptide Science. 19:681-691
Sarcopenia is the loss of muscle mass and function, affecting up to 70% of patients with advanced liver disease. Liver cirrhosis is characterized by an altered glucose metabolism, lipid oxidation, ketogenesis and protein catabolism, leading to the lo
Autor:
Alfonso J. Cruz-Jentoft
Publikováno v:
Current Protein & Peptide Science. 19:668-672
β-hydroxy-β-methylbutyrate (HMB) is a metabolite derived from leucine and its ketoacid alpha- ketoisocaproate. Leucine has a role in regulating protein synthesis in muscle cells, and HMB seems to be a key active metabolite in such regulation. HMB h
Publikováno v:
Current Protein & Peptide Science. 19:612-622
Clusterin is a multifunctional glycoprotein whose role in cells has generated a great controversy in recent years. Since its discovery, numerous studies have linked clusterin expression deregulation with various physio-pathological processes such as