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Publikováno v:
Current Protein & Peptide Science. 19:889-899
Leprosy is an infectious disease caused by non-cultivable bacteria Mycobacterium leprae. Ridley and Jopling classified the disease into five polar forms, Tuberculoid (TT) and Lepromatous (LL), in between two forms of the disease Borderline tuberculoi
Publikováno v:
Current Pharmaceutical Design. 15:3274-3282
Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic peptide. T cell receptors (TCR
Publikováno v:
Current Pharmaceutical Design. 14:454-464
Heme oxygenase-1 (HO-1) is the rate-limiting enzyme of ferroheme metabolic pathway, which has the functions of anti-oxidation, anti-inflammatory, anti-apoptosis and anti-smooth muscle hyperplasia. Furthermore, HO-1 exerts a protective action in the d
Autor:
Soichi Tanabe
Publikováno v:
Current Protein & Peptide Science. 8:109-118
Allergic diseases affect atopic individuals, who synthesize specific Immunoglobulins E (IgE) to environmental allergens, usually proteins or glycoproteins. These allergens include grass and tree pollens, indoor allergens such as house dust mites and
Autor:
Jorge Kalil, Pablo Maria Alberto Pomerantzeff, Sandra E. Oshiro, Ana C. Tanaka, Luiza Guilherme, Kellen C. Faé
Publikováno v:
Current Protein & Peptide Science. 8:39-44
Molecular mimicry between streptococcal and human proteins has been proposed as the triggering factor leading to autoimmunity in rheumatic fever (RF) and rheumatic heart disease (RHD). In this review we focus on the studies on genetic susceptibility
Autor:
Franz-Georg Hanisch, Tanja Ninkovic
Publikováno v:
Current Protein & Peptide Science. 7:307-315
Until about 1990 there was general consent about the assumption that only protein and peptide antigens have the capacity of CD4(+) or CD8(+) T-cell stimulation. Since about ten years evidence is now accumulating that carbohydrate-peptide epitopes do
Autor:
Shizuo Akira, Tsuneyasu Kaisho
Publikováno v:
Current Molecular Medicine. 3:373-385
Higher animals establish host defense by orchestrating innate and adaptive immunity. This is mediated by professional antigen presenting cells, i.e. dendritic cells (DCs). DCs can incorporate pathogens, produce a variety of cytokines, maturate, and p