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Publikováno v:
CNS & Neurological Disorders - Drug Targets. 21:108-117
Abstract:: Ethanolamine is a bioactive molecule found in several cells, including those in the central nervous system (CNS). In the brain, ethanolamine and ethanolamine-related molecules have emerged as prodrug moieties that can promote drug movement
Autor:
Surendra Kumar Nayak
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 21:689-703
Background: COVID-19 has become a pandemic with higher morbidity and mortality rates after its start from Wuhan city of China. The infection by RNA virus, also known as SARS-CoV-2 or 2019-nCoV, from the beta class of coronaviruses, has been found to
Publikováno v:
Current Protein & Peptide Science. 21:1103-1142
Topoisomerases are reported to resolve the topological problems of DNA during several cellular processes, such as DNA replication, transcription, recombination, and chromatin remodeling. Two types of topoisomerases (Topo I and II) accomplish their de
Autor:
Xin Sun, Qing Luo, Li Liang, Wei Liu, Huaichuan Duan, Jianping Hu, Xinyu Liu, Gang Zhao, Yichen Hu, Hua Wan, Lianxin Peng, Ya Gan, Hubing Shi
Publikováno v:
Current Protein & Peptide Science. 21:1027-1039
Indoleamine 2, 3-dioxygenase 1 (IDO1) is the only rate-limiting enzyme outside the liver that catalyzes the oxidation and cracking of indole rings in the tryptophan along the kynurenine pathway (KP). The overactivation of IDO1 is closely related to t
Publikováno v:
Current Protein & Peptide Science. 21:1011-1026
Aminoglycosides and β-lactams are the most commonly used antimicrobial agents in clinical practice. This occurs because they are capable of acting in the treatment of acute bacterial infections. However, the effectiveness of antibiotics has been con
Publikováno v:
Current Protein & Peptide Science. 20:1218-1225
Out of multiple therapeutic targets, DPP-IV is the lead target for the treatment of type 2 diabetes. Natural products have always been available for the possible lead generation against various diseases and disorders. In the present review, we have c
Autor:
Alex Monteiro, Jéssika de Oliveira Viana, Luciana Scotti, Engene Muratov, Marcus Tullius Scotti
Publikováno v:
Current Protein & Peptide Science. 20:1135-1150
Sexually Transmitted Diseases (STDs) refer to a variety of clinical syndromes and infections caused by pathogens that can be acquired and transmitted through sexual activity. Among STDs widely reported in the literature, viral sexual diseases have be
Publikováno v:
Current Protein & Peptide Science. 19:909-923
Obesity is a metabolic syndrome leading to several health problems such as hypertension, heart attack, type II diabetes, and even cancer. Carbonic anhydrase VA (CAVA) is a mitochondrial enzyme which is directly associated with the glucose homeostasis
Publikováno v:
Current Computer-Aided Drug Design. 14:117-124
Background Cytosolic Phospholipase A2 (cPLA2), an important isoform of PLA2 that mediates the release of arachidonic acid, plays a role in the pathogenesis of Spinal Cord Injury (SCI). The expression and activation of Cpla2 are significantly higher i
Publikováno v:
Current Pharmaceutical Design. 23:4705-4715
Tumour reversion represents a promising field of investigation. The occurrence of cancer reversion both in vitro and in vivo has been ascertained by an increasing number of reports. The reverting process may be triggered in a wide range of different