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Autor:
Haojie Huang, Huarui Lu
Publikováno v:
Current Drug Targets. 12:1235-1244
The forkhead box O (FoxO) transcription factors are known to be involved in many physiological and pathological processes including apoptosis, cell cycle arrest, stress resistance, glucose metabolism, cellular differentiation and development, and tum
Publikováno v:
Current Pharmaceutical Design. 17:1944-1961
Urokinase (uPA) was originally identified in human urine for its ability to catalyse the transformation of plasminogen into its active form, plasmin which degrades fibrin and extracellular matrix components. Two major, functionally independent region
Publikováno v:
Scopus-Elsevier
Resolution of inflammation, an actively coordinated program, is essential to maintain host health. It involves effective removal of inflammatory stimuli and the spatio-temporal control of leukocyte trafficking as well as chemical mediator generation.
Autor:
Gabriela Mustata, Ahmet Bakan, Mei Li, Michael W. Epperly, Ivet Bahar, Lin Zhang, Joel S. Greenberger, Nicki Zevola, Jian Yu
Publikováno v:
Current Topics in Medicinal Chemistry. 11:281-290
PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2 family member and a key mediator of apoptosis induced by a wide variety of stimuli. PUMA is particularly important in initiating radiation-induced apoptosis and dama
Autor:
Reinhold Schäfer, Balazs Gyorffy
Publikováno v:
Scopus-Elsevier
The small GTP-binding proteins HRAS, KRAS and NRAS belong to a family of oncoproteins associated with many types of human cancer. Signal transduction processes initiated at receptor tyrosine kinases converge on RAS proteins which serve as molecular s
Publikováno v:
Current Protein & Peptide Science. 11:498-514
In an era that has been dominated by Structural Biology for the last 30-40 years, a dramatic change of focus towards sequence analysis has spurred the advent of the genome projects and the resultant diverging sequence/structure deficit. The central c
Publikováno v:
Current Stem Cell Research & Therapy. 5:227-232
Human pluripotential stem cells including both embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) possess self-renewing potency and pluripotentency and can differentiate into virtually any somatic cell type. These features are a d
Autor:
Johanna Myllyharju
Publikováno v:
Current Pharmaceutical Design. 15:3878-3885
Hypoxia-inducible transcription factor (HIF) is the master regulator of hypoxia-inducible genes involved in the mediation of survival and adaptive responses to insufficient oxygen availability, such as genes involved in hematopoesis, angiogenesis, ir
Autor:
Helen C. Ardley
Publikováno v:
Current Pharmaceutical Design. 15:3697-3715
The ubiquitin proteasome system (UPS) plays a fundamental role in maintaining the correct balance of protein levels inside all living cells. Degradation of proteins by this pathway is essential for most cellular processes including cell signalling, D
Autor:
A. Toste Rego, Denis Verger, Rémi Fronzes, Gabriel Waksman, Eric Durand, Guoyu Meng, Vidya Chandran
Publikováno v:
Infectious Disorders - Drug Targets. 9:518-547
Gram-negative bacteria have evolved diverse secretion systems/machineries to translocate substrates across the cell envelope. These various machineries fulfil a wide variety of functions but are also essential for pathogenic bacteria to infect human