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Autor:
Surendra Kumar Nayak
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 21:689-703
Background: COVID-19 has become a pandemic with higher morbidity and mortality rates after its start from Wuhan city of China. The infection by RNA virus, also known as SARS-CoV-2 or 2019-nCoV, from the beta class of coronaviruses, has been found to
Autor:
Xin Sun, Qing Luo, Li Liang, Wei Liu, Huaichuan Duan, Jianping Hu, Xinyu Liu, Gang Zhao, Yichen Hu, Hua Wan, Lianxin Peng, Ya Gan, Hubing Shi
Publikováno v:
Current Protein & Peptide Science. 21:1027-1039
Indoleamine 2, 3-dioxygenase 1 (IDO1) is the only rate-limiting enzyme outside the liver that catalyzes the oxidation and cracking of indole rings in the tryptophan along the kynurenine pathway (KP). The overactivation of IDO1 is closely related to t
Publikováno v:
Current Protein & Peptide Science. 21:1011-1026
Aminoglycosides and β-lactams are the most commonly used antimicrobial agents in clinical practice. This occurs because they are capable of acting in the treatment of acute bacterial infections. However, the effectiveness of antibiotics has been con
Autor:
S. E. Barbour, W. P. Wilkins
Publikováno v:
Current Drug Targets. 9:683-697
Group VI phospholipase A2 (PLA2) is a family of acyl hydrolases that targets the sn-2 fatty acid on the glycerophospholipid (GPL) backbone. These enzymes are grouped together based on structural homologies and catalytic activities that are independen
Autor:
Jolanta M Wodzinska
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 5:279-292
Transglutaminases (TGases), a family of enzymes that catalyze the formation of epsilon-(gamma-glutamyl)lysine isopeptide linkage, play an important physiological role in hemostasis, wound healing, assembly and remodeling of the extracellular matrix,
Publikováno v:
Current Protein & Peptide Science. 5:225-234
In spite of the relevance of the results obtained through the clinical application of chemotherapeutic agents (reverse transcriptase and proteinase inhibitors) that are able to prolong the life span of affected people, acquired immunodeficiency syndr
Autor:
Nikos G. Oikonomakos
Publikováno v:
Current Protein and Peptide Science 3:6(Dec2002):561-586
The regulation of the hepatic glucose output through glycogenolysis is an important target for type 2 diabetes therapy. Glycogenolysis is catalyzed in liver, muscle and brain by tissue specific isoforms of glycogen phosphorylase (GP). Because of its